Mate discrimination among subspecies through a conserved olfactory pathway

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Communication mechanisms underlying the sexual isolation of species are poorly understood. Using four subspecies of Drosophila mojavensis as a model, we identify two behaviorally active, male-specific pheromones. One functions as a conserved male antiaphrodisiac in all subspecies and acts via gustation. The second induces female receptivity via olfaction exclusively in the two subspecies that produce it. Genetic analysis of the cognate receptor for the olfactory pheromone indicates an important role for this sensory pathway in promoting sexual isolation of subspecies, in combination with auditory signals. Unexpectedly, the peripheral sensory pathway detecting this pheromone is conserved molecularly, physiologically, and anatomically across subspecies. These observations imply that subspecies-specific behaviors arise from differential interpretation of the same peripheral cue, reminiscent of sexually conserved detection but dimorphic interpretation of male pheromones in Drosophila melanogaster. Our results reveal that, during incipient speciation, pheromone production, detection, and interpretation do not necessarily evolve in a coordinated manner.


  • Mohammed A. Khallaf
  • Thomas O. Auer
  • Veit Grabe
  • Ana Depetris-Chauvin
  • Byrappa Ammagarahalli
  • Dan Dan Zhang
  • Sofía Lavista-Llanos
  • Filip Kaftan
  • Jerrit Weißflog
  • Luciano M. Matzkin
  • Stephanie M. Rollmann
  • Christer Löfstedt
  • Aleš Svatoš
  • Hany K.M. Dweck
  • Silke Sachse
  • Richard Benton
  • Bill S. Hansson
  • Markus Knaden
Enheter & grupper
Externa organisationer
  • Max Planck Institute for Chemical Ecology
  • University of Lausanne
  • University of Cincinnati
  • University of Arizona

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Evolutionsbiologi
TidskriftScience Advances
Utgåva nummer25
StatusPublished - 2020
Peer review utfördJa