Memorability of photographs in subjective cognitive decline and mild cognitive impairment: Implications for cognitive assessment

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Introduction: Impaired long-term memory is a defining feature of mild cognitive impairment (MCI). We tested whether this impairment is item specific, limited to some memoranda, whereas some remain consistently memorable. Methods: We conducted item-based analyses of long-term visual recognition memory. Three hundred ninety-four participants (healthy controls, subjective cognitive decline [SCD], and MCI) in the multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) were tested with images from a pool of 835 photographs. Results: We observed consistent memorability for images in healthy controls, SCD, and MCI, predictable by a neural network trained on another healthy sample. Looking at memorability differences between groups, we identified images that could successfully categorize group membership with higher success and a substantial image reduction than the original image set. Discussion: Individuals with SCD and MCI show consistent memorability for specific items, while other items show significant diagnosticity. Certain stimulus features could optimize diagnostic assessment, while others could support memory.

Detaljer

Författare
  • Wilma A. Bainbridge
  • Hartmut Schütze
  • Arturo Cardenas-Blanco
  • Coraline Metzger
  • Laura Dobisch
  • Daniel Bittner
  • Wenzel Glanz
  • Annika Spottke
  • Janna Rudolph
  • Frederic Brosseron
  • Katharina Buerger
  • Daniel Janowitz
  • Klaus Fliessbach
  • Michael Heneka
  • Christoph Laske
  • Martina Buchmann
  • Oliver Peters
  • Dominik Diesing
  • Siyao Li
  • Josef Priller
  • Eike Jakob Spruth
  • Slawek Altenstein
  • Anja Schneider
  • Barbara Kofler
  • Stefan Teipel
  • Ingo Kilimann
  • Jens Wiltfang
  • Claudia Bartels
  • Steffen Wolfsgruber
  • Michael Wagner
  • Frank Jessen
  • Chris I. Baker
  • Emrah Düzel
Enheter & grupper
Externa organisationer
  • US National Institute of Mental Health
  • Otto von Guericke University Magdeburg
  • German Center for Neurodegenerative Diseases
  • University Hospital Magdeburg
  • University of Bonn
  • Universitätsklinikum Bonn
  • University of Tübingen
  • Charité Universitätsmedizin Berlin
  • Universitätsmedizin Rostock
  • University Medical Center Göttingen
  • University of Cologne
  • University College London
  • University Hospital Munich
  • University of Göttingen
  • Free University of Berlin
  • Humboldt University of Berlin
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi

Nyckelord

Originalspråkengelska
Sidor (från-till)610-618
Antal sidor9
TidskriftAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volym11
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa