Memory formation orchestrates the wiring of adult-born hippocampal neurons into brain circuits

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

During memory formation, structural rearrangements of dendritic spines provide a mean to durably modulate synaptic connectivity within neuronal networks. New neurons generated throughout the adult life in the dentate gyrus of the hippocampus contribute to learning and memory. As these neurons become incorporated into the network, they generate huge numbers of new connections that modify hippocampal circuitry and functioning. However, it is yet unclear as to how the dynamic process of memory formation influences their synaptic integration into neuronal circuits. New memories are established according to a multistep process during which new information is first acquired and then consolidated to form a stable memory trace. Upon recall, memory is transiently destabilized and vulnerable to modification. Using contextual fear conditioning, we found that learning was associated with an acceleration of dendritic spines formation of adult-born neurons, and that spine connectivity becomes strengthened after memory consolidation. Moreover, we observed that afferent connectivity onto adult-born neurons is enhanced after memory retrieval, while extinction training induces a change of spine shapes. Together, these findings reveal that the neuronal activity supporting memory processes strongly influences the structural dendritic integration of adult-born neurons into pre-existing neuronal circuits. Such change of afferent connectivity is likely to impact the overall wiring of hippocampal network, and consequently, to regulate hippocampal function.

Detaljer

Författare
  • Petnoi Petsophonsakul
  • Kevin Richetin
  • Trinovita Andraini
  • Laurent Roybon
  • Claire Rampon
Enheter & grupper
Externa organisationer
  • University of Indonesia
  • Université Paul Sabatier
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)2585-2601
TidskriftBrain Structure and Function
Volym222
Utgåva nummer6
Tidigt onlinedatum2017 jan 6
StatusPublished - 2017
PublikationskategoriForskning
Peer review utfördJa