Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis

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Abstract

We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n = ~ 38,000 for LTL and ~ 81,000 for ALS in the European population; n = ~ 23,000 for LTL and ~ 4,100 for ALS in the Asian population). We further evaluated mediation roles of lipids in the pathway from LTL to ALS. The odds ratio per standard deviation decrease of LTL on ALS was 1.10 (95% CI 0.93–1.31, p = 0.274) in the European population and 0.75 (95% CI 0.53–1.07, p = 0.116) in the Asian population. This null association was also detected between LTL and frontotemporal dementia in the European population. However, we found that an indirect effect of LTL on ALS might be mediated by low density lipoprotein (LDL) or total cholesterol (TC) in the European population. These results were robust against extensive sensitivity analyses. Overall, our MR study did not support the direct causal association between LTL and the ALS risk in neither population, but provided suggestive evidence for the mediation role of LDL or TC on the influence of LTL and ALS in the European population. © 2020, The Author(s).

Detaljer

Författare
  • International FTD-Genomics Consortium (IFGC)
  • Yixin Gao
  • MARIA LANDQVIST WALDÖ
  • Karin Nilsson
  • Christer Nilsson
  • Ping Zeng
Enheter & grupper
Externa organisationer
  • Xuzhou Medical University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicinsk genetik
  • Neurovetenskaper
Originalspråkengelska
Artikelnummer12184
TidskriftScientific Reports
Volym10
Utgåva nummer1
StatusPublished - 2020
PublikationskategoriForskning
Peer review utfördJa