Metabolic Factors and the Risk of Colorectal Cancer in 580,000 Men and Women in the Metabolic Syndrome and Cancer Project (Me-Can)

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Metabolic Factors and the Risk of Colorectal Cancer in 580,000 Men and Women in the Metabolic Syndrome and Cancer Project (Me-Can). / Stocks, Tanja; Lukanova, Annekatrin; Bjorge, Tone; Ulmer, Hanno; Manjer, Jonas; Almquist, Martin; Concin, Hans; Engeland, Anders; Hallmans, Goran; Nagel, Gabriele; Tretli, Steinar; Veierod, Marit B.; Jonsson, Hakan; Stattin, Par.

I: Cancer, Vol. 117, Nr. 11, 2011, s. 2398-2407.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Stocks, T, Lukanova, A, Bjorge, T, Ulmer, H, Manjer, J, Almquist, M, Concin, H, Engeland, A, Hallmans, G, Nagel, G, Tretli, S, Veierod, MB, Jonsson, H & Stattin, P 2011, 'Metabolic Factors and the Risk of Colorectal Cancer in 580,000 Men and Women in the Metabolic Syndrome and Cancer Project (Me-Can)', Cancer, vol. 117, nr. 11, s. 2398-2407. https://doi.org/10.1002/cncr.25772

APA

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Stocks T, Lukanova A, Bjorge T, Ulmer H, Manjer J, Almquist M, Concin H, Engeland A, Hallmans G, Nagel G, Tretli S, Veierod MB, Jonsson H, Stattin P. 2011. Metabolic Factors and the Risk of Colorectal Cancer in 580,000 Men and Women in the Metabolic Syndrome and Cancer Project (Me-Can). Cancer. 117(11):2398-2407. https://doi.org/10.1002/cncr.25772

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Stocks, Tanja ; Lukanova, Annekatrin ; Bjorge, Tone ; Ulmer, Hanno ; Manjer, Jonas ; Almquist, Martin ; Concin, Hans ; Engeland, Anders ; Hallmans, Goran ; Nagel, Gabriele ; Tretli, Steinar ; Veierod, Marit B. ; Jonsson, Hakan ; Stattin, Par. / Metabolic Factors and the Risk of Colorectal Cancer in 580,000 Men and Women in the Metabolic Syndrome and Cancer Project (Me-Can). I: Cancer. 2011 ; Vol. 117, Nr. 11. s. 2398-2407.

RIS

TY - JOUR

T1 - Metabolic Factors and the Risk of Colorectal Cancer in 580,000 Men and Women in the Metabolic Syndrome and Cancer Project (Me-Can)

AU - Stocks, Tanja

AU - Lukanova, Annekatrin

AU - Bjorge, Tone

AU - Ulmer, Hanno

AU - Manjer, Jonas

AU - Almquist, Martin

AU - Concin, Hans

AU - Engeland, Anders

AU - Hallmans, Goran

AU - Nagel, Gabriele

AU - Tretli, Steinar

AU - Veierod, Marit B.

AU - Jonsson, Hakan

AU - Stattin, Par

PY - 2011

Y1 - 2011

N2 - BACKGROUND: The metabolic syndrome (MetS) has been related to an increased risk of colorectal cancer, but the modest size of previous studies precluded detailed characterization of the role of individual MetS factors and their interaction on risk. METHODS: In the Metabolic Syndrome and Cancer Project (Me-Can), data on body mass index (BMI), blood pressure, and blood levels of glucose, cholesterol, and triglycerides were available for 578,700 men and women. The mean age of participants at baseline was 44 years, and the mean follow-up was 12 years. Relative risks (RR) of colorectal cancer per 1 standard deviation increment in Z score of factors and for a combined MetS score, were calculated from Cox regression models, including adjustment for potential confounders. RESULTS: During follow-up, 2834 men and 1861 women were diagnosed with colorectal cancer. The RR of colorectal cancer for the MetS score was 1.25 (95% confidence interval [CI], 1.18-1.32) in men, and 1.14 (95% CI, 1.06-1.22) in women. Significant associations also were observed in men for BMI (RR, 1.07; 95% CI, 1.02-1.13), blood pressure (RR, 1.10; 95% CI, 1.02-1.18), and triglycerides (RR, 1.17; 95% CI, 1.06-1.28) and, in women, for BMI (RR, 1.08; 95% CI, 1.01-1.15). There was no significant positive interaction between the metabolic factors on risk. CONCLUSIONS: The combination of metabolic factors and some separate factors was related to an increased risk of colorectal cancer, but there was no interaction between metabolic factors. Cancer 2011; 117: 2398-407. (C) 2010 American Cancer Society.

AB - BACKGROUND: The metabolic syndrome (MetS) has been related to an increased risk of colorectal cancer, but the modest size of previous studies precluded detailed characterization of the role of individual MetS factors and their interaction on risk. METHODS: In the Metabolic Syndrome and Cancer Project (Me-Can), data on body mass index (BMI), blood pressure, and blood levels of glucose, cholesterol, and triglycerides were available for 578,700 men and women. The mean age of participants at baseline was 44 years, and the mean follow-up was 12 years. Relative risks (RR) of colorectal cancer per 1 standard deviation increment in Z score of factors and for a combined MetS score, were calculated from Cox regression models, including adjustment for potential confounders. RESULTS: During follow-up, 2834 men and 1861 women were diagnosed with colorectal cancer. The RR of colorectal cancer for the MetS score was 1.25 (95% confidence interval [CI], 1.18-1.32) in men, and 1.14 (95% CI, 1.06-1.22) in women. Significant associations also were observed in men for BMI (RR, 1.07; 95% CI, 1.02-1.13), blood pressure (RR, 1.10; 95% CI, 1.02-1.18), and triglycerides (RR, 1.17; 95% CI, 1.06-1.28) and, in women, for BMI (RR, 1.08; 95% CI, 1.01-1.15). There was no significant positive interaction between the metabolic factors on risk. CONCLUSIONS: The combination of metabolic factors and some separate factors was related to an increased risk of colorectal cancer, but there was no interaction between metabolic factors. Cancer 2011; 117: 2398-407. (C) 2010 American Cancer Society.

KW - epidemiology

KW - cohort studies

KW - colorectal neoplasms

KW - overweight

KW - blood

KW - pressure

KW - blood glucose

KW - cholesterol

KW - triglycerides

KW - metabolic syndrome

KW - X

U2 - 10.1002/cncr.25772

DO - 10.1002/cncr.25772

M3 - Article

VL - 117

SP - 2398

EP - 2407

JO - Cancer

JF - Cancer

SN - 1097-0142

IS - 11

ER -