Metabolic Syndrome and Breast Cancer in the Me-Can (Metabolic Syndrome and Cancer) Project

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Metabolic Syndrome and Breast Cancer in the Me-Can (Metabolic Syndrome and Cancer) Project. / Bjorge, Tone; Lukanova, Annekatrin; Jonsson, Hakan; Tretli, Steinar; Ulmer, Hanno; Manjer, Jonas; Stocks, Tanja; Selmer, Randi; Nagel, Gabriele; Almquist, Martin; Concin, Hans; Hallmans, Goran; Haggstrom, Christel; Stattin, Par; Engeland, Anders.

I: Cancer Epidemiology Biomarkers & Prevention, Vol. 19, Nr. 7, 2010, s. 1737-1745.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Bjorge, T, Lukanova, A, Jonsson, H, Tretli, S, Ulmer, H, Manjer, J, Stocks, T, Selmer, R, Nagel, G, Almquist, M, Concin, H, Hallmans, G, Haggstrom, C, Stattin, P & Engeland, A 2010, 'Metabolic Syndrome and Breast Cancer in the Me-Can (Metabolic Syndrome and Cancer) Project', Cancer Epidemiology Biomarkers & Prevention, vol. 19, nr. 7, s. 1737-1745. https://doi.org/10.1158/1055-9965.EPI-10-0230

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Bjorge T, Lukanova A, Jonsson H, Tretli S, Ulmer H, Manjer J, Stocks T, Selmer R, Nagel G, Almquist M, Concin H, Hallmans G, Haggstrom C, Stattin P, Engeland A. 2010. Metabolic Syndrome and Breast Cancer in the Me-Can (Metabolic Syndrome and Cancer) Project. Cancer Epidemiology Biomarkers & Prevention. 19(7):1737-1745. https://doi.org/10.1158/1055-9965.EPI-10-0230

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Bjorge, Tone ; Lukanova, Annekatrin ; Jonsson, Hakan ; Tretli, Steinar ; Ulmer, Hanno ; Manjer, Jonas ; Stocks, Tanja ; Selmer, Randi ; Nagel, Gabriele ; Almquist, Martin ; Concin, Hans ; Hallmans, Goran ; Haggstrom, Christel ; Stattin, Par ; Engeland, Anders. / Metabolic Syndrome and Breast Cancer in the Me-Can (Metabolic Syndrome and Cancer) Project. I: Cancer Epidemiology Biomarkers & Prevention. 2010 ; Vol. 19, Nr. 7. s. 1737-1745.

RIS

TY - JOUR

T1 - Metabolic Syndrome and Breast Cancer in the Me-Can (Metabolic Syndrome and Cancer) Project

AU - Bjorge, Tone

AU - Lukanova, Annekatrin

AU - Jonsson, Hakan

AU - Tretli, Steinar

AU - Ulmer, Hanno

AU - Manjer, Jonas

AU - Stocks, Tanja

AU - Selmer, Randi

AU - Nagel, Gabriele

AU - Almquist, Martin

AU - Concin, Hans

AU - Hallmans, Goran

AU - Haggstrom, Christel

AU - Stattin, Par

AU - Engeland, Anders

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery Research Unit (013242220), Emergency medicine/Medicine/Surgery (013240200)

PY - 2010

Y1 - 2010

N2 - Background: Few studies have assessed the metabolic syndrome (MetS) as an entity in relation to breast cancer risk, and results have been inconsistent. We aimed to examine the association between MetS factors (individually and combined) and risk of breast cancer incidence and mortality. Methods: Two hundred ninety thousand women from Austria, Norway, and Sweden were enrolled during 1974-2005, with measurements of height, weight, blood pressure, and levels of glucose, cholesterol, and triglycerides. Relative risks (RR) of breast cancer were estimated using Cox proportional hazards regression for each MetS factor in quintiles and for standardized levels (z-scores) and for a composite z-score for the MetS. Results: There were 4,862 incident cases of breast cancer and 633 deaths from breast cancer identified. In women below age 50, there was a decreased risk of incident cancer for the MetS (per 1-unit increment of z-score; RR, 0.83; 95% confidence interval, 0.76-0.90) as well as for the individual factors (except for glucose). The lowest risks were seen among the heaviest women. In women above age 60, there was an increased risk of breast cancer mortality for the MetS (RR, 1.23; 95% confidence interval, 1.04-1.45) and for blood pressure and glucose. The strongest association with mortality was seen for increased glucose concentrations. Conclusions: The MetS was associated with a decreased risk of incident breast cancer in women below age 50 with high body mass index, and with an increased risk of breast cancer mortality in women above 60. Impact: Lifestyle interventions as recommended for cardiovascular disease prevention may be of value to prevent breast cancer mortality in postmenopausal women. Cancer Epidemiol Biomarkers Prev; 19(7); 1737-45. (C) 2010 AACR.

AB - Background: Few studies have assessed the metabolic syndrome (MetS) as an entity in relation to breast cancer risk, and results have been inconsistent. We aimed to examine the association between MetS factors (individually and combined) and risk of breast cancer incidence and mortality. Methods: Two hundred ninety thousand women from Austria, Norway, and Sweden were enrolled during 1974-2005, with measurements of height, weight, blood pressure, and levels of glucose, cholesterol, and triglycerides. Relative risks (RR) of breast cancer were estimated using Cox proportional hazards regression for each MetS factor in quintiles and for standardized levels (z-scores) and for a composite z-score for the MetS. Results: There were 4,862 incident cases of breast cancer and 633 deaths from breast cancer identified. In women below age 50, there was a decreased risk of incident cancer for the MetS (per 1-unit increment of z-score; RR, 0.83; 95% confidence interval, 0.76-0.90) as well as for the individual factors (except for glucose). The lowest risks were seen among the heaviest women. In women above age 60, there was an increased risk of breast cancer mortality for the MetS (RR, 1.23; 95% confidence interval, 1.04-1.45) and for blood pressure and glucose. The strongest association with mortality was seen for increased glucose concentrations. Conclusions: The MetS was associated with a decreased risk of incident breast cancer in women below age 50 with high body mass index, and with an increased risk of breast cancer mortality in women above 60. Impact: Lifestyle interventions as recommended for cardiovascular disease prevention may be of value to prevent breast cancer mortality in postmenopausal women. Cancer Epidemiol Biomarkers Prev; 19(7); 1737-45. (C) 2010 AACR.

U2 - 10.1158/1055-9965.EPI-10-0230

DO - 10.1158/1055-9965.EPI-10-0230

M3 - Article

VL - 19

SP - 1737

EP - 1745

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1538-7755

IS - 7

ER -