Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

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Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). / Cust, Anne E.; Kaaks, Rudolf; Friedenreich, Christine; Bonnet, Fabrice; Laville, Martine; Tjonneland, Anne; Olsen, Anja; Overvad, Kim; Jakobsen, Marianne Uhre; Chajes, Veronique; Clavel-Chapelon, Frangoise; Boutron-Ruault, Marie-Christine; Linseisen, Jakob; Lukanova, Annekatrin; Boeing, Heiner; Pischon, Tobias; Trichopoulou, Antonia; Christina, Bamia; Trichopoulos, Dimitrios; Palli, Domenico; Berrino, Franco; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; Gram, Inger Torhild; Lund, Eiliv; Quiros, J. R.; Travier, Nomie; Garcia, Carmen Martinez; Larranaga, Nerea; Chirlaque, Maria-Dolores; Ardanaz, Eva; Berglund, Göran; Lundin, Eva; Bueno-De-Mesquita, H. Bas; Franzel, J. B. van Duijnhoven; Peeters, Petra H. M.; Bingham, Sheila; Khaw, Kay-Tee; Allen, Naomi; Key, Tim; Ferrari, Pietro; Rinaldi, Sabina; Slimani, Nadia; Riboli, Elio.

I: Endocrine-Related Cancer, Vol. 14, Nr. 3, 2007, s. 755-767.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Cust, AE, Kaaks, R, Friedenreich, C, Bonnet, F, Laville, M, Tjonneland, A, Olsen, A, Overvad, K, Jakobsen, MU, Chajes, V, Clavel-Chapelon, F, Boutron-Ruault, M-C, Linseisen, J, Lukanova, A, Boeing, H, Pischon, T, Trichopoulou, A, Christina, B, Trichopoulos, D, Palli, D, Berrino, F, Panico, S, Tumino, R, Sacerdote, C, Gram, IT, Lund, E, Quiros, JR, Travier, N, Garcia, CM, Larranaga, N, Chirlaque, M-D, Ardanaz, E, Berglund, G, Lundin, E, Bueno-De-Mesquita, HB, Franzel, JBVD, Peeters, PHM, Bingham, S, Khaw, K-T, Allen, N, Key, T, Ferrari, P, Rinaldi, S, Slimani, N & Riboli, E 2007, 'Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)', Endocrine-Related Cancer, vol. 14, nr. 3, s. 755-767. https://doi.org/10.1677/ERC-07-0132

APA

CBE

Cust AE, Kaaks R, Friedenreich C, Bonnet F, Laville M, Tjonneland A, Olsen A, Overvad K, Jakobsen MU, Chajes V, Clavel-Chapelon F, Boutron-Ruault M-C, Linseisen J, Lukanova A, Boeing H, Pischon T, Trichopoulou A, Christina B, Trichopoulos D, Palli D, Berrino F, Panico S, Tumino R, Sacerdote C, Gram IT, Lund E, Quiros JR, Travier N, Garcia CM, Larranaga N, Chirlaque M-D, Ardanaz E, Berglund G, Lundin E, Bueno-De-Mesquita HB, Franzel JBVD, Peeters PHM, Bingham S, Khaw K-T, Allen N, Key T, Ferrari P, Rinaldi S, Slimani N, Riboli E. 2007. Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Endocrine-Related Cancer. 14(3):755-767. https://doi.org/10.1677/ERC-07-0132

MLA

Vancouver

Author

Cust, Anne E. ; Kaaks, Rudolf ; Friedenreich, Christine ; Bonnet, Fabrice ; Laville, Martine ; Tjonneland, Anne ; Olsen, Anja ; Overvad, Kim ; Jakobsen, Marianne Uhre ; Chajes, Veronique ; Clavel-Chapelon, Frangoise ; Boutron-Ruault, Marie-Christine ; Linseisen, Jakob ; Lukanova, Annekatrin ; Boeing, Heiner ; Pischon, Tobias ; Trichopoulou, Antonia ; Christina, Bamia ; Trichopoulos, Dimitrios ; Palli, Domenico ; Berrino, Franco ; Panico, Salvatore ; Tumino, Rosario ; Sacerdote, Carlotta ; Gram, Inger Torhild ; Lund, Eiliv ; Quiros, J. R. ; Travier, Nomie ; Garcia, Carmen Martinez ; Larranaga, Nerea ; Chirlaque, Maria-Dolores ; Ardanaz, Eva ; Berglund, Göran ; Lundin, Eva ; Bueno-De-Mesquita, H. Bas ; Franzel, J. B. van Duijnhoven ; Peeters, Petra H. M. ; Bingham, Sheila ; Khaw, Kay-Tee ; Allen, Naomi ; Key, Tim ; Ferrari, Pietro ; Rinaldi, Sabina ; Slimani, Nadia ; Riboli, Elio. / Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). I: Endocrine-Related Cancer. 2007 ; Vol. 14, Nr. 3. s. 755-767.

RIS

TY - JOUR

T1 - Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

AU - Cust, Anne E.

AU - Kaaks, Rudolf

AU - Friedenreich, Christine

AU - Bonnet, Fabrice

AU - Laville, Martine

AU - Tjonneland, Anne

AU - Olsen, Anja

AU - Overvad, Kim

AU - Jakobsen, Marianne Uhre

AU - Chajes, Veronique

AU - Clavel-Chapelon, Frangoise

AU - Boutron-Ruault, Marie-Christine

AU - Linseisen, Jakob

AU - Lukanova, Annekatrin

AU - Boeing, Heiner

AU - Pischon, Tobias

AU - Trichopoulou, Antonia

AU - Christina, Bamia

AU - Trichopoulos, Dimitrios

AU - Palli, Domenico

AU - Berrino, Franco

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Gram, Inger Torhild

AU - Lund, Eiliv

AU - Quiros, J. R.

AU - Travier, Nomie

AU - Garcia, Carmen Martinez

AU - Larranaga, Nerea

AU - Chirlaque, Maria-Dolores

AU - Ardanaz, Eva

AU - Berglund, Göran

AU - Lundin, Eva

AU - Bueno-De-Mesquita, H. Bas

AU - Franzel, J. B. van Duijnhoven

AU - Peeters, Petra H. M.

AU - Bingham, Sheila

AU - Khaw, Kay-Tee

AU - Allen, Naomi

AU - Key, Tim

AU - Ferrari, Pietro

AU - Rinaldi, Sabina

AU - Slimani, Nadia

AU - Riboli, Elio

PY - 2007

Y1 - 2007

N2 - To clarify the role of metabolic factors in endometrial carcinogenesis, we conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), and examined the relation between prediagnostic plasma lipids, lipoproteins, and glucose, the metabolic syndrome (MetS; a cluster of metabolic factors) and endometrial cancer risk. Among pre- and postmenopausal women, 284 women developed endometrial cancer during follow-up. Using risk set sampling, 546 matched control subjects were selected. From conditional logistic regression models, high-density lipoprotein cholesterol (HDL-C) levels were inversely associated with risk body mass index (BMI)-adjusted relative risk (FR) for top versus bottom quartile 0.61 (95% confidence intervals (CI) 0.38-0.97), P-trend= 0.02). Glucose levels were positively associated with risk (BMI-adjusted RR top versus bottom quartile 1.69 (95% Cl 0.99-2.90), P-trend, = 0.03), which appeared stronger among postmenopausal women (BMI-adjusted RR top versus bottom tertile 2.61 (95% Cl 1.46-4.66), P-trend=0.0006, P-heterogeneity=0.13) and never-users of exogenous hormones (P-heterogeneity=0-005 for oral contraceptive (OC) use and 0.05 for hormone replacement therapy-use). The associations of HDL-C and glucose with risk were no longer statistically significant after further adjustment for obesity-related hormones. Plasma total cholesterol, Low-density lipoprotein cholesterol (LDL-C), and triglycerides were not significantly related to overall risk. The presence of MetS was associated with risk (RR 2.12 (95% CI 1.51-2.97)), which increased with the number of MetS factors (P-trend=0.02). An increasing number of MetS factors other than waist circumference, however, was marginally significantly associated with risk only in women with waist circumference above the median (P-interaction=0-01). None of the associations differed significantly by fasting status. These findings suggest that metabolic abnormalities and obesity may act synergistically to increase endometrial cancer risk.

AB - To clarify the role of metabolic factors in endometrial carcinogenesis, we conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), and examined the relation between prediagnostic plasma lipids, lipoproteins, and glucose, the metabolic syndrome (MetS; a cluster of metabolic factors) and endometrial cancer risk. Among pre- and postmenopausal women, 284 women developed endometrial cancer during follow-up. Using risk set sampling, 546 matched control subjects were selected. From conditional logistic regression models, high-density lipoprotein cholesterol (HDL-C) levels were inversely associated with risk body mass index (BMI)-adjusted relative risk (FR) for top versus bottom quartile 0.61 (95% confidence intervals (CI) 0.38-0.97), P-trend= 0.02). Glucose levels were positively associated with risk (BMI-adjusted RR top versus bottom quartile 1.69 (95% Cl 0.99-2.90), P-trend, = 0.03), which appeared stronger among postmenopausal women (BMI-adjusted RR top versus bottom tertile 2.61 (95% Cl 1.46-4.66), P-trend=0.0006, P-heterogeneity=0.13) and never-users of exogenous hormones (P-heterogeneity=0-005 for oral contraceptive (OC) use and 0.05 for hormone replacement therapy-use). The associations of HDL-C and glucose with risk were no longer statistically significant after further adjustment for obesity-related hormones. Plasma total cholesterol, Low-density lipoprotein cholesterol (LDL-C), and triglycerides were not significantly related to overall risk. The presence of MetS was associated with risk (RR 2.12 (95% CI 1.51-2.97)), which increased with the number of MetS factors (P-trend=0.02). An increasing number of MetS factors other than waist circumference, however, was marginally significantly associated with risk only in women with waist circumference above the median (P-interaction=0-01). None of the associations differed significantly by fasting status. These findings suggest that metabolic abnormalities and obesity may act synergistically to increase endometrial cancer risk.

U2 - 10.1677/ERC-07-0132

DO - 10.1677/ERC-07-0132

M3 - Article

VL - 14

SP - 755

EP - 767

JO - Endocrine-Related Cancer

JF - Endocrine-Related Cancer

SN - 1479-6821

IS - 3

ER -