Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. (c) 2006 Elsevier Inc. All rights reserved.

Detaljer

Författare
  • Theeraphon Piacham
  • C Isarankura-Na-Ayuldhya
  • C Nantasenamat
  • S Yainoy
  • Lei Ye
  • Leif Bülow
  • V Prachayasittikul
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Biologiska vetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)925-930
TidskriftBiochemical and Biophysical Research Communications
Volym341
Utgivningsnummer4
StatusPublished - 2006
PublikationskategoriForskning
Peer review utfördJa