Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase

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Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase. / Piacham, Theeraphon; Isarankura-Na-Ayuldhya, C; Nantasenamat, C; Yainoy, S; Ye, Lei; Bülow, Leif; Prachayasittikul, V.

I: Biochemical and Biophysical Research Communications, Vol. 341, Nr. 4, 2006, s. 925-930.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Piacham, Theeraphon ; Isarankura-Na-Ayuldhya, C ; Nantasenamat, C ; Yainoy, S ; Ye, Lei ; Bülow, Leif ; Prachayasittikul, V. / Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase. I: Biochemical and Biophysical Research Communications. 2006 ; Vol. 341, Nr. 4. s. 925-930.

RIS

TY - JOUR

T1 - Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase

AU - Piacham, Theeraphon

AU - Isarankura-Na-Ayuldhya, C

AU - Nantasenamat, C

AU - Yainoy, S

AU - Ye, Lei

AU - Bülow, Leif

AU - Prachayasittikul, V

PY - 2006

Y1 - 2006

N2 - Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. (c) 2006 Elsevier Inc. All rights reserved.

AB - Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. (c) 2006 Elsevier Inc. All rights reserved.

KW - molecular

KW - modeling

KW - SOD mimic

KW - SOD

KW - superoxide dismutase

KW - antibiotic

KW - bacitracin

U2 - 10.1016/j.bbrc.2006.01.045

DO - 10.1016/j.bbrc.2006.01.045

M3 - Article

VL - 341

SP - 925

EP - 930

JO - Biochemical and Biophysical Research Communications

T2 - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 1090-2104

IS - 4

ER -