Metal-on-metal joint bearings and hematopoetic malignancy A review

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Metal-on-metal joint bearings and hematopoetic malignancy A review. / Wagner, Philippe; Olsson, Håkan; Ranstam, Jonas; Robertsson, Otto; Zheng, Ming Hao; Lidgren, Lars.

I: Acta Orthopaedica, Vol. 83, Nr. 6, 2012, s. 553-558.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

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T1 - Metal-on-metal joint bearings and hematopoetic malignancy A review

AU - Wagner, Philippe

AU - Olsson, Håkan

AU - Ranstam, Jonas

AU - Robertsson, Otto

AU - Zheng, Ming Hao

AU - Lidgren, Lars

PY - 2012

Y1 - 2012

N2 - This is a review of the hip arthroplasty era. We concentrate on new metal bearings, surface replacements, and the lessons not learned, and we highlight recent reports on malignancies and joint implants. A low incidence of blood malignancies has been found in bone marrow taken at prosthetic surgery. The incidence is increased after replacement with knee implants that release very low systemic levels of metal ions. A carcinogenic effect of the high levels of metal ions released by large metal-on-metal implants cannot be excluded. Ongoing Swedish implant registry studies going back to 1975 can serve as a basis for evaluation of this risk.

AB - This is a review of the hip arthroplasty era. We concentrate on new metal bearings, surface replacements, and the lessons not learned, and we highlight recent reports on malignancies and joint implants. A low incidence of blood malignancies has been found in bone marrow taken at prosthetic surgery. The incidence is increased after replacement with knee implants that release very low systemic levels of metal ions. A carcinogenic effect of the high levels of metal ions released by large metal-on-metal implants cannot be excluded. Ongoing Swedish implant registry studies going back to 1975 can serve as a basis for evaluation of this risk.

U2 - 10.3109/17453674.2012.747055

DO - 10.3109/17453674.2012.747055

M3 - Review article

VL - 83

SP - 553

EP - 558

JO - Acta Orthopaedica

T2 - Acta Orthopaedica

JF - Acta Orthopaedica

SN - 1745-3682

IS - 6

ER -