Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Malignant peripheral nerve sheath tumor (MPNST) is a rare and highly aggressive disease with no evidence of effect from adjuvant therapy. It is further associated with the hereditary syndrome neurofibromatosis type 1 (NF1). Silencing of the tumor suppressor gene RASSF1A through DNA promoter hypermethylation is known to be involved in cancer development, but its impact in MPNSTs remains unsettled.

Detaljer

Författare
  • Stine A Danielsen
  • Guro E Lind
  • Matthias Kolberg
  • Maren Høland
  • Bodil Bjerkehagen
  • Kirsten Sundby Hall
  • Eva van den Berg
  • Fredrik Mertens
  • Sigbjørn Smeland
  • Piero Picci
  • Ragnhild A Lothe
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicinsk genetik
Originalspråkengelska
Sidor (från-till)63-69
TidskriftNeuro-Oncology
Volym17
Utgåva nummer1
StatusPublished - 2015
PublikationskategoriForskning
Peer review utfördJa

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