Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Bibtex

@article{c44624b8491f4672a830e167d1e9e79e,
title = "Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study",
abstract = "A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.",
author = "Aghiad Ghazal and Mark Gontsarik and Kutter, {J{\"o}rg P.} and Lafleur, {Josiane P.} and Davoud Ahmadvand and Ana Labrador and Stefan Salentinig and Anan Yaghmur",
year = "2017",
month = "1",
day = "5",
doi = "10.1021/acs.jpclett.6b02468",
language = "English",
volume = "8",
pages = "73--79",
journal = "The Journal of Physical Chemistry Letters",
issn = "1948-7185",
publisher = "The American Chemical Society (ACS)",
number = "1",

}