Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study

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Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles : A Synchrotron Small-Angle X-ray Scattering (SAXS) Study. / Ghazal, Aghiad; Gontsarik, Mark; Kutter, Jörg P.; Lafleur, Josiane P.; Ahmadvand, Davoud; Labrador, Ana; Salentinig, Stefan; Yaghmur, Anan.

I: Journal of Physical Chemistry Letters, Vol. 8, Nr. 1, 05.01.2017, s. 73-79.

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Ghazal, Aghiad ; Gontsarik, Mark ; Kutter, Jörg P. ; Lafleur, Josiane P. ; Ahmadvand, Davoud ; Labrador, Ana ; Salentinig, Stefan ; Yaghmur, Anan. / Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles : A Synchrotron Small-Angle X-ray Scattering (SAXS) Study. I: Journal of Physical Chemistry Letters. 2017 ; Vol. 8, Nr. 1. s. 73-79.

RIS

TY - JOUR

T1 - Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles

T2 - The Journal of Physical Chemistry Letters

AU - Ghazal, Aghiad

AU - Gontsarik, Mark

AU - Kutter, Jörg P.

AU - Lafleur, Josiane P.

AU - Ahmadvand, Davoud

AU - Labrador, Ana

AU - Salentinig, Stefan

AU - Yaghmur, Anan

PY - 2017/1/5

Y1 - 2017/1/5

N2 - A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.

AB - A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.

UR - http://www.scopus.com/inward/record.url?scp=85018521726&partnerID=8YFLogxK

U2 - 10.1021/acs.jpclett.6b02468

DO - 10.1021/acs.jpclett.6b02468

M3 - Article

VL - 8

SP - 73

EP - 79

JO - The Journal of Physical Chemistry Letters

JF - The Journal of Physical Chemistry Letters

SN - 1948-7185

IS - 1

ER -