MicroRNA in Prostate, Bladder, and Kidney Cancer: A Systematic Review

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MicroRNA in Prostate, Bladder, and Kidney Cancer: A Systematic Review. / Catto, James W. F.; Alcaraz, Antonio; Bjartell, Anders; White, Ralph De Vere; Evans, Christopher P.; Fussel, Susanne; Hamdy, Freddie C.; Kallioniemi, Olli; Mengual, Lourdes; Schlomm, Thorsten; Visakorpi, Tapio.

I: European Urology, Vol. 59, Nr. 5, 2011, s. 671-681.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Harvard

Catto, JWF, Alcaraz, A, Bjartell, A, White, RDV, Evans, CP, Fussel, S, Hamdy, FC, Kallioniemi, O, Mengual, L, Schlomm, T & Visakorpi, T 2011, 'MicroRNA in Prostate, Bladder, and Kidney Cancer: A Systematic Review', European Urology, vol. 59, nr. 5, s. 671-681. https://doi.org/10.1016/j.eururo.2011.01.044

APA

Catto, J. W. F., Alcaraz, A., Bjartell, A., White, R. D. V., Evans, C. P., Fussel, S., ... Visakorpi, T. (2011). MicroRNA in Prostate, Bladder, and Kidney Cancer: A Systematic Review. European Urology, 59(5), 671-681. https://doi.org/10.1016/j.eururo.2011.01.044

CBE

Catto JWF, Alcaraz A, Bjartell A, White RDV, Evans CP, Fussel S, Hamdy FC, Kallioniemi O, Mengual L, Schlomm T, Visakorpi T. 2011. MicroRNA in Prostate, Bladder, and Kidney Cancer: A Systematic Review. European Urology. 59(5):671-681. https://doi.org/10.1016/j.eururo.2011.01.044

MLA

Vancouver

Author

Catto, James W. F. ; Alcaraz, Antonio ; Bjartell, Anders ; White, Ralph De Vere ; Evans, Christopher P. ; Fussel, Susanne ; Hamdy, Freddie C. ; Kallioniemi, Olli ; Mengual, Lourdes ; Schlomm, Thorsten ; Visakorpi, Tapio. / MicroRNA in Prostate, Bladder, and Kidney Cancer: A Systematic Review. I: European Urology. 2011 ; Vol. 59, Nr. 5. s. 671-681.

RIS

TY - JOUR

T1 - MicroRNA in Prostate, Bladder, and Kidney Cancer: A Systematic Review

AU - Catto, James W. F.

AU - Alcaraz, Antonio

AU - Bjartell, Anders

AU - White, Ralph De Vere

AU - Evans, Christopher P.

AU - Fussel, Susanne

AU - Hamdy, Freddie C.

AU - Kallioniemi, Olli

AU - Mengual, Lourdes

AU - Schlomm, Thorsten

AU - Visakorpi, Tapio

PY - 2011

Y1 - 2011

N2 - Context: MicroRNAs (miRNA) are noncoding RNAs that post- transcriptionally regulate gene expression. Their altered expression and function have been observed in most urologic cancers. MiRNAs represent potential disease biomarkers and novel therapeutic targets. Objective: To review and evaluate the evidence implicating miRNAs in the pathogenesis of prostate cancer (PCa), bladder cancer (BCa), and renal cancer. Evidence acquisition: A systematic review was performed using PubMed and Embase to search for reports using strings for microRNA, non- coding RNA, cancer, prostate, bladder, and renal cancer. Identified manuscripts were retrieved and references searched. Selected studies were required to concentrate on the role of miRNA in these urologic cancers. Evidence synthesis: We reviewed articles that focus on this topic. More than 40 miRNAs have been implicated in urologic cancer and many target common carcinogenic pathways. In particular, apoptosis avoidance, cell proliferation, epithelial- to- mesenchymal transition, angiogenic signalling, and the generation of androgen independence are targeted or facilitated by more than one miRNA. Little work has been done to evaluate the translational applications for this knowledge to date. Novel therapeutic strategies have been developed and are under investigation to selectively modulate miRNAs; such work would potentially enable personalised tumour therapy. Conclusions: MiRNAs appear to be important modulators of urologic cancer. Their expression is frequently altered in these tumours, and many are functionally implicated in their pathogenesis. They require evaluation to determine the translational role and therapeutic potential for this knowledge. Crown Copyright (C) 2011 Published by Elsevier B. V. on behalf of European Association of Urology. All rights reserved.

AB - Context: MicroRNAs (miRNA) are noncoding RNAs that post- transcriptionally regulate gene expression. Their altered expression and function have been observed in most urologic cancers. MiRNAs represent potential disease biomarkers and novel therapeutic targets. Objective: To review and evaluate the evidence implicating miRNAs in the pathogenesis of prostate cancer (PCa), bladder cancer (BCa), and renal cancer. Evidence acquisition: A systematic review was performed using PubMed and Embase to search for reports using strings for microRNA, non- coding RNA, cancer, prostate, bladder, and renal cancer. Identified manuscripts were retrieved and references searched. Selected studies were required to concentrate on the role of miRNA in these urologic cancers. Evidence synthesis: We reviewed articles that focus on this topic. More than 40 miRNAs have been implicated in urologic cancer and many target common carcinogenic pathways. In particular, apoptosis avoidance, cell proliferation, epithelial- to- mesenchymal transition, angiogenic signalling, and the generation of androgen independence are targeted or facilitated by more than one miRNA. Little work has been done to evaluate the translational applications for this knowledge to date. Novel therapeutic strategies have been developed and are under investigation to selectively modulate miRNAs; such work would potentially enable personalised tumour therapy. Conclusions: MiRNAs appear to be important modulators of urologic cancer. Their expression is frequently altered in these tumours, and many are functionally implicated in their pathogenesis. They require evaluation to determine the translational role and therapeutic potential for this knowledge. Crown Copyright (C) 2011 Published by Elsevier B. V. on behalf of European Association of Urology. All rights reserved.

KW - MicroRNA

KW - Gene regulation

KW - Prostate

KW - Bladder

KW - Kidney

KW - Cancer

U2 - 10.1016/j.eururo.2011.01.044

DO - 10.1016/j.eururo.2011.01.044

M3 - Review article

VL - 59

SP - 671

EP - 681

JO - European Urology

JF - European Urology

SN - 1873-7560

IS - 5

ER -