microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


New neurons, originating from the subventricular zone, are continuously integrating into neuronal circuitry in the olfactory bulb (OB). Using a transgenic sensor mouse, we found that adult-born OB interneurons express microRNA-125 (miR-125), whereas the pre-existing developmentally generated OB interneurons represent a unique population of cells in the adult brain, without miR-125 activity. Stable inhibition of miR-125 in newborn OB neurons resulted in enhanced dendritic morphogenesis, as well as in increased synaptic activation in response to odour sensory stimuli. These data demonstrate that miR-125 controls functional synaptic integration of adult-born OB interneurons. Our results also suggest that absence of an otherwise broadly expressed miRNA is a novel mechanism with which to achieve neuronal subtype specification.


Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Utvecklingsbiologi
Sidor (från-till)1580-1588
TidskriftDevelopment: For advances in developmental biology and stem cells
Utgåva nummer7
StatusPublished - 2014
Peer review utfördJa

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