microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

New neurons, originating from the subventricular zone, are continuously integrating into neuronal circuitry in the olfactory bulb (OB). Using a transgenic sensor mouse, we found that adult-born OB interneurons express microRNA-125 (miR-125), whereas the pre-existing developmentally generated OB interneurons represent a unique population of cells in the adult brain, without miR-125 activity. Stable inhibition of miR-125 in newborn OB neurons resulted in enhanced dendritic morphogenesis, as well as in increased synaptic activation in response to odour sensory stimuli. These data demonstrate that miR-125 controls functional synaptic integration of adult-born OB interneurons. Our results also suggest that absence of an otherwise broadly expressed miRNA is a novel mechanism with which to achieve neuronal subtype specification.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Utvecklingsbiologi
Originalspråkengelska
Sidor (från-till)1580-1588
TidskriftDevelopment: For advances in developmental biology and stem cells
Volym141
Utgåva nummer7
StatusPublished - 2014
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Petri, R., 2017, Lund: Lund University: Faculty of Medicine. 76 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

Malin Åkerblom, 2014, Molecular Neurogenetics, Faculty of Medicine, Lund University. 137 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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