Mining the Proteome Associated with Rheumatic and Autoimmune Diseases

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

A steady increase in the incidence of osteoarthritis and other rheumatic diseases has been observed in recent decades, including autoimmune conditions such as rheumatoid arthritis, spondyloarthropathies, systemic lupus erythematosus, systemic sclerosis, and Sjögren's syndrome. Rheumatic and autoimmune diseases (RADs) are characterized by the inflammation of joints, muscles, or other connective tissues. In addition to often experiencing debilitating mobility and pain, RAD patients are also at a higher risk of suffering comorbidities such as cardiovascular or infectious events. Given the socioeconomic impact of RADs, broad research efforts have been dedicated to these diseases worldwide. In the present work, we applied literature mining platforms to identify "popular" proteins closely related to RADs. The platform is based on publicly available literature. The results not only will enable the systematic prioritization of candidates to perform targeted proteomics studies but also may lead to a greater insight into the key pathogenic processes of these disorders.

Detaljer

Författare
  • Cristina Ruiz-Romero
  • Maggie P.Y. Lam
  • Peter Nilsson
  • Patrik Önnerfjord
  • Paul J. Utz
  • Jennifer E. Van Eyk
  • Vidya Venkatraman
  • Justyna Fert-Bober
  • Fiona E. Watt
  • Francisco J. Blanco
Enheter & grupper
Externa organisationer
  • University of A Coruña
  • KTH Royal Institute of Technology
  • Stanford University
  • Cedars-Sinai Medical Center
  • University of Colorado
  • University of Oxford
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Reumatologi och inflammation

Nyckelord

Originalspråkengelska
Sidor (från-till)4231-4239
TidskriftJournal of Proteome Research
Volym18
Utgåva nummer12
Tidigt onlinedatum2019 okt 10
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa