Minor components with smooth muscle relaxing properties from scented myrrh (Commiphora guidotti)

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Abstract

All sesquiterpenes present in a sample of scented myrrh were isolated and characterised. Seven compounds, with cadinane, guaiane, oplopane, and eudesmane skeletons, were obtained, of which two are new and two are reported from a natural source for the first time. The major component, T-cadinol, has previously been shown to possess smooth muscle-relaxing properties, and the major purpose of the investigation was to compare the effects of the minor and more polar sesquiterpenes with that of T-cadinol in the rat aorta. Like T-cadinol, the minor sesquiterpenes are more efficient in reducing K(+)-induced contractions than those induced by the alpha-adrenoceptor agonist phenylephrine, however, they were all less potent than T-cadinol.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Läkemedelskemi
  • Dermatologi och venereologi
  • Farmakologi och toxikologi

Nyckelord

Originalspråkengelska
Sidor (från-till)251-254
TidskriftPlanta Medica
Volym63
Utgivningsnummer3
StatusPublished - 1997
PublikationskategoriForskning
Peer review utfördJa