Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

HSC aging is clinically associated with risk of anemia, immune compromise, and malignancy. Mansell et al. show that mitochondrial activity is directly linked to age-related performance of HSCs and that its perturbation has direct consequences for HSC function, resulting in alleviation or prevention of hematopoietic aging.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • University College London
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cell- och molekylärbiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)241-256.e6
TidskriftCell Stem Cell
Volym28
Utgåva nummer2
Tidigt onlinedatum2020 okt 20
StatusPublished - 2021
PublikationskategoriForskning
Peer review utfördJa