Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Bibtex

@article{dd8e7d9bf04747cba7324fb0bd762f23,
title = "Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function",
abstract = "HSC aging is clinically associated with risk of anemia, immune compromise, and malignancy. Mansell et al. show that mitochondrial activity is directly linked to age-related performance of HSCs and that its perturbation has direct consequences for HSC function, resulting in alleviation or prevention of hematopoietic aging.",
keywords = "Aging, Hematopoietc Stem Cell, Lineage bias, Mitochondria, Mitochondrial Membrane Potential, Mitoquinol, Transcription Rate",
author = "Els Mansell and Valgardur Sigurdsson and Elitza Deltcheva and John Brown and Chela James and Kenichi Miharada and Shamit Soneji and Jonas Larsson and Tariq Enver",
note = "{\textcopyright} 2020 The Authors. Published by Elsevier Inc.",
year = "2021",
doi = "10.1016/j.stem.2020.09.018",
language = "English",
volume = "28",
pages = "241--256.e6",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "2",

}