Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

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Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function. / Mansell, Els; Sigurdsson, Valgardur; Deltcheva, Elitza; Brown, John; James, Chela; Miharada, Kenichi; Soneji, Shamit; Larsson, Jonas; Enver, Tariq.

I: Cell Stem Cell, Vol. 28, Nr. 2, 2021, s. 241-256.e6.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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TY - JOUR

T1 - Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

AU - Mansell, Els

AU - Sigurdsson, Valgardur

AU - Deltcheva, Elitza

AU - Brown, John

AU - James, Chela

AU - Miharada, Kenichi

AU - Soneji, Shamit

AU - Larsson, Jonas

AU - Enver, Tariq

N1 - © 2020 The Authors. Published by Elsevier Inc.

PY - 2021

Y1 - 2021

N2 - HSC aging is clinically associated with risk of anemia, immune compromise, and malignancy. Mansell et al. show that mitochondrial activity is directly linked to age-related performance of HSCs and that its perturbation has direct consequences for HSC function, resulting in alleviation or prevention of hematopoietic aging.

AB - HSC aging is clinically associated with risk of anemia, immune compromise, and malignancy. Mansell et al. show that mitochondrial activity is directly linked to age-related performance of HSCs and that its perturbation has direct consequences for HSC function, resulting in alleviation or prevention of hematopoietic aging.

KW - Aging

KW - Hematopoietc Stem Cell

KW - Lineage bias

KW - Mitochondria

KW - Mitochondrial Membrane Potential

KW - Mitoquinol

KW - Transcription Rate

U2 - 10.1016/j.stem.2020.09.018

DO - 10.1016/j.stem.2020.09.018

M3 - Article

C2 - 33086034

AN - SCOPUS:85095443376

VL - 28

SP - 241-256.e6

JO - Cell Stem Cell

JF - Cell Stem Cell

SN - 1934-5909

IS - 2

ER -