Mitogen- and stress-activated protein kinase 1 is required for specific signaling responses in dopamine-denervated mouse striatum, but is not necessary for l-DOPA-induced dyskinesia

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Bibtex

@article{a6018d3c0cc44c0fa64b9ad04e86288d,
title = "Mitogen- and stress-activated protein kinase 1 is required for specific signaling responses in dopamine-denervated mouse striatum, but is not necessary for l-DOPA-induced dyskinesia",
abstract = "In advanced Parkinson's disease, l-DOPA treatment causes the appearance of abnormal involuntary movements or l-DOPA-induced dyskinesia (LID). LID results in part from l-DOPA-induced activation of extracellular signal-regulated kinase (ERK) in the dopamine-denervated striatum. Activated ERK triggers nuclear responses, including phosphorylation of mitogen- and stress-activated protein kinase 1 (MSK1) and histone H3, and transcription of genes such as FosB. To determine the role of MSK1, wild type and MSK1 knockout mice with unilateral 6-hydroxydopamine lesion in the dorsolateral striatum were chronically treated with l-DOPA. The absence of MSK1 had no effect on the lesion or l-DOPA-induced ERK activation, but reduced l-DOPA-induced phosphorylation of histone H3 and FosB accumulation in the dopamine-denervated striatum. MSK1 deficiency also prevented the increase in Gαolf, the stimulatory α subunit of G protein coupling striatal dopamine D1 receptor to adenylyl cyclase. However, the intensity of LID was similar in MSK1-deficient and wild type mice. In conclusion, l-DOPA-induced activation of MSK1 contributes to histone H3 phosphorylation, induction of FosB, and Gαolf up-regulation but appears not to be necessary for the development of LID.",
keywords = "6-OHDA, Extracellular signal-regulated kinase, L-DOPA-induced dyskinesia, Parkinson's disease, Signaling",
author = "Cristina Alcacer and Fanny Charbonnier-Beaupel and Jean-Christophe Corvol and Jean-Antoine Girault and Denis Herv{\'e}",
year = "2014",
month = nov,
day = "7",
doi = "10.1016/j.neulet.2014.09.018",
language = "English",
volume = "583",
pages = "76--80",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier",

}