Mixed airway and pulmonary parenchymal disease in patients with primary Sjögren's Syndrome - a six-year follow-up

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title = "Mixed airway and pulmonary parenchymal disease in patients with primary Sj{\"o}gren's Syndrome - a six-year follow-up",
abstract = "OBJECTIVE: To assess pulmonary function and Chronic Obstructive Pulmonary Disease (COPD) development over time in patients with primary Sj{\"o}gren's Syndrome (pSS) and the association between pulmonary function, radiographic findings, respiratory symptoms and clinical features of pSS, taking cigarette consumption into account.METHODS: Forty patients with pSS (mean age 66 yrs, range 42-81 yrs, 39 women), previously participating in a cross-sectional study on pulmonary involvement in pSS, were re-assessed by pulmonary function tests after a mean follow-up time of six years. At follow-up, patients were also assessed by high-resolution computed tomography (HRCT) of the chest and for pSS disease activity, respiratory symptoms and cigarette consumption.RESULTS: Patients with pSS showed significantly decreased percentages of predicted total lung capacity (TLC), residual volume (RV), RV/ TLC ratio and diffusing capacity of the lungs for carbon monoxide (DL,CO), and an increased percentage of predicted forced expiratory volume in one second/vital capacity (FEV1/VC) ratio from baseline to follow-up. The proportion of COPD did not change significantly from baseline to follow-up (38{\%} vs. 40{\%}). Radiographic signs of bronchial involvement and interstitial lung disease were found in 38{\%} of the patients, respectively.CONCLUSION: Both airway and pulmonary parenchymal disease were commonly found in pSS patients, with a co-existence of both an obstructive and a restrictive pulmonary function pattern, where the latter tended to deteriorate over time. COPD was still a common finding. Airway and pulmonary involvement may be underdiagnosed in pSS, why special attention to clinical assessment of pulmonary involvement in pSS patients is mandated.",
author = "Nilsson, {Anna Matilda} and Aaltonen, {H Laura} and Peter Olsson and Persson, {Hans Lennart} and Roger Hesselstrand and Elke Theander and Per Wollmer and Thomas Mandl",
year = "2020",
doi = "10.3899/jrheum.200247",
language = "English",
volume = "47",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "J Rheumatol Publ Co",
number = "6",