MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia

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MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia. / Panagopoulos, Ioannis; Lilljebjörn, Henrik; Strömbeck, Bodil; Hjorth, Lars; Olofsson, Tor; Johansson, Bertil.

I: Haematologica, Vol. 91, Nr. 9, 2006, s. 1287-1288.

Forskningsoutput: TidskriftsbidragLetter

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T1 - MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia

AU - Panagopoulos, Ioannis

AU - Lilljebjörn, Henrik

AU - Strömbeck, Bodil

AU - Hjorth, Lars

AU - Olofsson, Tor

AU - Johansson, Bertil

PY - 2006

Y1 - 2006

N2 - AML/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecular genetic features of MLL/GAS7 and the clinical impact of t(11;17) are discussed.

AB - AML/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecular genetic features of MLL/GAS7 and the clinical impact of t(11;17) are discussed.

KW - GAS7

KW - MLL

KW - ALL

KW - translocation

KW - fusion

M3 - Letter

VL - 91

SP - 1287

EP - 1288

JO - Haematologica-The Hematology Journal

T2 - Haematologica-The Hematology Journal

JF - Haematologica-The Hematology Journal

SN - 1592-8721

IS - 9

ER -