Models for control of intravenous anesthesia

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKapitel samlingsverk

Abstract

Modeling is fundamental to both feed-forward and feedback control. Within automated anesthesia the two paradigms are usually referred to as target-controlled infusion (TCI) and closed-loop drug delivery, respectively. In both cases, the objective is to control a system with anesthetic drug infusion rate as input, and (measured) clinical effect as output. The input is related to the output through the pharmacokinetics (PK) and pharmacodynamics (PD) of the patient. This chapter gives an introduction to PKPD modeling in automated anesthesia management, intended to be accessible to both anesthesiology and (control) engineering researchers. The following topics are discussed: the role of modeling; the classic PKPD structure used in clinical pharmacology; anesthesia modeling and identification for closed-loop control; inter-patient variability and model uncertainty; disturbance, noise and equipment models. The chapter emphasizes electroencephalogram-guided control of propofol.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • University of British Columbia
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Reglerteknik
Originalspråkengelska
Titel på värdpublikationAutomated drug delivery in anesthesia
FörlagElsevier
StatusAccepted/In press - 2020
PublikationskategoriForskning
Peer review utfördJa

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