Molecular basis of cell-biomaterial interaction: Insights gained from transcriptomic and proteomic studies

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

With the growing interest in clinical interventions that involve medical devices, the role for new biomaterials in modern medicine is currently expanding at a phenomenal rate. Failure of most implant materials stems from an inability to predict and control biological phenomena, such as protein adsorption and cell interaction, resulting in an inappropriate host response to the materials. Contemporary advances in biological investigation are starting to shift focus in the biomaterials field, in particular with the advent of high-throughput methodologies for gene and protein expression profiling. Here, we examine the role that emerging transcriptomic and proteomic technologies could play in relation to biomaterial development and usage. Moreover, a number of studies are highlighted which have utilized such approaches in order to try to create a deeper understanding of cell-biomaterial interactions and, hence, improve our ability to predict and control the biocompatibility of new materials. (c) 2006 Elsevier Ltd. All rights reserved.

Detaljer

Författare
  • William M. Gallagher
  • Iseult Lynch
  • Lorcan T. Allen
  • Ian Miller
  • Stephen C. Penney
  • Darran P. O'Connor
  • Stephen Pennington
  • Alan K. Keenan
  • Kenneth A. Dawson
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Bioteknisk apparatteknik

Nyckelord

Originalspråkengelska
Sidor (från-till)5871-5882
TidskriftBiomaterials
Volym27
Utgåva nummer35
StatusPublished - 2006
PublikationskategoriForskning
Peer review utfördJa