Monitoring levels of preservative sensitivity in Europe - A 10-year overview (1991-2000)

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.

Detaljer

Författare
  • JD Wilkinson
  • S Shaw
  • KE Andersen
  • FM Brandao
  • DP Bruynzeel
  • Magnus Bruze
  • JMG Camarasa
  • TL Diepgen
  • G Ducombs
  • PJ Frosch
  • A Goossens
  • JM Lachappelle
  • A Lahti
  • T Menne
  • S Seidenari
  • A Tosti
  • JE Wahlberg
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Dermatologi och venereologi

Nyckelord

Originalspråkengelska
Sidor (från-till)207-210
TidskriftContact Dermatitis
Volym46
Utgåva nummer4
StatusPublished - 2002
PublikationskategoriForskning
Peer review utfördJa