Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study

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Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study. / Kristinsson, Sigurdur Y.; Tang, Min; Pfeiffer, Ruth M.; Bjorkholm, Magnus; Goldin, Lynn R.; Blimark, Cecilie; Mellqvist, Ulf-Henrik; Wahlin, Anders; Turesson, Ingemar; Landgren, Ola.

I: Haematologica, Vol. 97, Nr. 6, 2012, s. 854-858.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Kristinsson, SY, Tang, M, Pfeiffer, RM, Bjorkholm, M, Goldin, LR, Blimark, C, Mellqvist, U-H, Wahlin, A, Turesson, I & Landgren, O 2012, 'Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study', Haematologica, vol. 97, nr. 6, s. 854-858. https://doi.org/10.3324/haematol.2011.054015

APA

Kristinsson, S. Y., Tang, M., Pfeiffer, R. M., Bjorkholm, M., Goldin, L. R., Blimark, C., ... Landgren, O. (2012). Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study. Haematologica, 97(6), 854-858. https://doi.org/10.3324/haematol.2011.054015

CBE

Kristinsson SY, Tang M, Pfeiffer RM, Bjorkholm M, Goldin LR, Blimark C, Mellqvist U-H, Wahlin A, Turesson I, Landgren O. 2012. Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study. Haematologica. 97(6):854-858. https://doi.org/10.3324/haematol.2011.054015

MLA

Vancouver

Author

Kristinsson, Sigurdur Y. ; Tang, Min ; Pfeiffer, Ruth M. ; Bjorkholm, Magnus ; Goldin, Lynn R. ; Blimark, Cecilie ; Mellqvist, Ulf-Henrik ; Wahlin, Anders ; Turesson, Ingemar ; Landgren, Ola. / Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study. I: Haematologica. 2012 ; Vol. 97, Nr. 6. s. 854-858.

RIS

TY - JOUR

T1 - Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study

AU - Kristinsson, Sigurdur Y.

AU - Tang, Min

AU - Pfeiffer, Ruth M.

AU - Bjorkholm, Magnus

AU - Goldin, Lynn R.

AU - Blimark, Cecilie

AU - Mellqvist, Ulf-Henrik

AU - Wahlin, Anders

AU - Turesson, Ingemar

AU - Landgren, Ola

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)

PY - 2012

Y1 - 2012

N2 - No comprehensive evaluation has been made to assess the risk of viral and bacterial infections among patients with monoclonal gammopathy of undetermined significance. Using population-based data from Sweden, we estimated risk of infections among 5,326 monoclonal gammopathy of undetermined significance patients compared to 20,161 matched controls. Patients with monoclonal gammopathy of undetermined significance had a 2-fold increased risk (P < 0.05) of developing any infection at 5- and 10-year follow up. More specifically, patients with monoclonal gammopathy of undetermined significance had an increased risk (P < 0.05) of bacterial (pneumonia, osteomyelitis, septicemia, pyelonephritis, cellulitis, endocarditis, and meningitis), and viral (influenza and herpes zoster) infections. Patients with monoclonal gammopathy of undetermined significance with M-protein concentrations over 2.5 g/dL at diagnosis had highest risks of infections. However, the risk was also increased (P < 0.05) among those with concentrations below 0.5 g/dL. Patients with monoclonal gammopathy of undetermined significance who developed infections had no excess risk of developing multiple myeloma, Waldenstrom macroglobulinemia or related malignancy. Our findings provide novel insights into the mechanisms behind infections in patients with plasma cell dyscrasias, and may have clinical implications.

AB - No comprehensive evaluation has been made to assess the risk of viral and bacterial infections among patients with monoclonal gammopathy of undetermined significance. Using population-based data from Sweden, we estimated risk of infections among 5,326 monoclonal gammopathy of undetermined significance patients compared to 20,161 matched controls. Patients with monoclonal gammopathy of undetermined significance had a 2-fold increased risk (P < 0.05) of developing any infection at 5- and 10-year follow up. More specifically, patients with monoclonal gammopathy of undetermined significance had an increased risk (P < 0.05) of bacterial (pneumonia, osteomyelitis, septicemia, pyelonephritis, cellulitis, endocarditis, and meningitis), and viral (influenza and herpes zoster) infections. Patients with monoclonal gammopathy of undetermined significance with M-protein concentrations over 2.5 g/dL at diagnosis had highest risks of infections. However, the risk was also increased (P < 0.05) among those with concentrations below 0.5 g/dL. Patients with monoclonal gammopathy of undetermined significance who developed infections had no excess risk of developing multiple myeloma, Waldenstrom macroglobulinemia or related malignancy. Our findings provide novel insights into the mechanisms behind infections in patients with plasma cell dyscrasias, and may have clinical implications.

KW - monoclonal gammopathy of undetermined significance

KW - infections

KW - multiple

KW - myeloma

KW - bacteria

KW - virus

U2 - 10.3324/haematol.2011.054015

DO - 10.3324/haematol.2011.054015

M3 - Article

VL - 97

SP - 854

EP - 858

JO - Haematologica-The Hematology Journal

T2 - Haematologica-The Hematology Journal

JF - Haematologica-The Hematology Journal

SN - 1592-8721

IS - 6

ER -