Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland

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Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland. / Hoyer, Birgit Bjerre; Ramlau-Hansen, Cecilia Host; Pedersen, Henning Sloth; Goralczyk, Katarzyna; Chumak, Lyubov; Jönsson, Bo A; Bonde, Jens Peter; Toft, Gunnar.

I: BMC Public Health, Vol. 15, Nr. 146, 146, 2015, s. 1-11.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Hoyer, BB, Ramlau-Hansen, CH, Pedersen, HS, Goralczyk, K, Chumak, L, Jönsson, BA, Bonde, JP & Toft, G 2015, 'Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland', BMC Public Health, vol. 15, nr. 146, 146, s. 1-11. https://doi.org/10.1186/s12889-015-1465-3

APA

Hoyer, B. B., Ramlau-Hansen, C. H., Pedersen, H. S., Goralczyk, K., Chumak, L., Jönsson, B. A., ... Toft, G. (2015). Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland. BMC Public Health, 15(146), 1-11. [146]. https://doi.org/10.1186/s12889-015-1465-3

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MLA

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Author

Hoyer, Birgit Bjerre ; Ramlau-Hansen, Cecilia Host ; Pedersen, Henning Sloth ; Goralczyk, Katarzyna ; Chumak, Lyubov ; Jönsson, Bo A ; Bonde, Jens Peter ; Toft, Gunnar. / Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland. I: BMC Public Health. 2015 ; Vol. 15, Nr. 146. s. 1-11.

RIS

TY - JOUR

T1 - Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland

AU - Hoyer, Birgit Bjerre

AU - Ramlau-Hansen, Cecilia Host

AU - Pedersen, Henning Sloth

AU - Goralczyk, Katarzyna

AU - Chumak, Lyubov

AU - Jönsson, Bo A

AU - Bonde, Jens Peter

AU - Toft, Gunnar

PY - 2015

Y1 - 2015

N2 - Background: Prior studies on the association between prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) and child motor development have found contradicting results. Using data collected in the INUENDO cohort in Kharkiv (Ukraine), Warsaw (Poland) and Greenland (N = 1,103) between the years 2002 and 2012, we examined relations of prenatal exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p, p'-DDE) and 2,2', 4,4', 5,5'-hexachlorobiphenyl (CB-153) on motor development and developmental milestones; crawling, standing-up and walking. Methods: CB-153 and p, p'-DDE were measured in maternal blood in second or third trimester of pregnancy. Motor development was measured in terms of the parentally assessed screening tool Developmental Coordination Disorder Questionnaire 2007 and developmental milestones were assessed via retrospective parental reports of child age at the first time of crawling, standing-up and walking. Results: We saw no associations between tertiles of CB-153 and p, p'-DDE or log-transformed exposures and retrospective reports of the developmental milestones crawling, standing-up and walking in infancy or the motor skills measured as developmental coordination disorder at young school age. Conclusions: In utero exposure to CB-153 and p, p'-DDE was not associated with parentally retrospectively assessed developmental milestones in infancy or parentally assessed motor skills at young school age. The use of a more sensitive outcome measure may be warranted if subtle effects should be identified.

AB - Background: Prior studies on the association between prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) and child motor development have found contradicting results. Using data collected in the INUENDO cohort in Kharkiv (Ukraine), Warsaw (Poland) and Greenland (N = 1,103) between the years 2002 and 2012, we examined relations of prenatal exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p, p'-DDE) and 2,2', 4,4', 5,5'-hexachlorobiphenyl (CB-153) on motor development and developmental milestones; crawling, standing-up and walking. Methods: CB-153 and p, p'-DDE were measured in maternal blood in second or third trimester of pregnancy. Motor development was measured in terms of the parentally assessed screening tool Developmental Coordination Disorder Questionnaire 2007 and developmental milestones were assessed via retrospective parental reports of child age at the first time of crawling, standing-up and walking. Results: We saw no associations between tertiles of CB-153 and p, p'-DDE or log-transformed exposures and retrospective reports of the developmental milestones crawling, standing-up and walking in infancy or the motor skills measured as developmental coordination disorder at young school age. Conclusions: In utero exposure to CB-153 and p, p'-DDE was not associated with parentally retrospectively assessed developmental milestones in infancy or parentally assessed motor skills at young school age. The use of a more sensitive outcome measure may be warranted if subtle effects should be identified.

KW - Child motor development

KW - Developmental milestones

KW - Dichlorodiphenyldichloroethylene (DDE)

KW - Organochlorines

KW - Polychlorinated

KW - biphenyls (PCBs)

KW - Prenatal exposure

U2 - 10.1186/s12889-015-1465-3

DO - 10.1186/s12889-015-1465-3

M3 - Article

VL - 15

SP - 1

EP - 11

JO - BMC Public Health

T2 - BMC Public Health

JF - BMC Public Health

SN - 1471-2458

IS - 146

M1 - 146

ER -