Mouse monoclonal antibodies with anti-A, anti-B and anti-A,B specificities; some superior to human polyclonal ABO reagents

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

A series of fusions using mouse myeloma cells and spleen cells from mice immunized with blood group substances or human red cells was performed with the aim of obtaining ABO antibodies suitable for routine blood grouping. Seven strongly agglutinating antibodies against antigens in the ABO system were obtained from 18 fusions. These antibodies were tested extensively in manual and automated routines, and six of them were found to be as good as or better than commercial polyclonal test sera of human origin.

Detaljer

Författare
  • L Messeter
  • T Brodin
  • Alan Chester
  • B Low
  • A Lundblad
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Hematologi
Originalspråkengelska
Sidor (från-till)185-194
TidskriftVox Sanguinis
Volym46
Utgåva nummer4
StatusPublished - 1984
PublikationskategoriForskning
Peer review utfördJa