Multicentre European study of thalamic stimulation for parkinsonian tremor: a 6 year follow-up

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Multicentre European study of thalamic stimulation for parkinsonian tremor: a 6 year follow-up. / Hariz, M I; Krack, P; Alesch, F; Augustinsson, L-E; Bosch, A; Ekberg, R; Johansson, F; Johnels, B; Meyerson, B A; N'Guyen, J-P; Pinter, M; Pollak, P; von Raison, F; Rehncrona, Stig; Speelman, J D; Sydow, O; Benabid, A-L.

I: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 79, Nr. 6, 2008, s. 694-699.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Hariz, MI, Krack, P, Alesch, F, Augustinsson, L-E, Bosch, A, Ekberg, R, Johansson, F, Johnels, B, Meyerson, BA, N'Guyen, J-P, Pinter, M, Pollak, P, von Raison, F, Rehncrona, S, Speelman, JD, Sydow, O & Benabid, A-L 2008, 'Multicentre European study of thalamic stimulation for parkinsonian tremor: a 6 year follow-up', Journal of Neurology, Neurosurgery and Psychiatry, vol. 79, nr. 6, s. 694-699. https://doi.org/10.1136/jnnp.2007.118653

APA

Hariz, M. I., Krack, P., Alesch, F., Augustinsson, L-E., Bosch, A., Ekberg, R., ... Benabid, A-L. (2008). Multicentre European study of thalamic stimulation for parkinsonian tremor: a 6 year follow-up. Journal of Neurology, Neurosurgery and Psychiatry, 79(6), 694-699. https://doi.org/10.1136/jnnp.2007.118653

CBE

Hariz MI, Krack P, Alesch F, Augustinsson L-E, Bosch A, Ekberg R, Johansson F, Johnels B, Meyerson BA, N'Guyen J-P, Pinter M, Pollak P, von Raison F, Rehncrona S, Speelman JD, Sydow O, Benabid A-L. 2008. Multicentre European study of thalamic stimulation for parkinsonian tremor: a 6 year follow-up. Journal of Neurology, Neurosurgery and Psychiatry. 79(6):694-699. https://doi.org/10.1136/jnnp.2007.118653

MLA

Vancouver

Author

Hariz, M I ; Krack, P ; Alesch, F ; Augustinsson, L-E ; Bosch, A ; Ekberg, R ; Johansson, F ; Johnels, B ; Meyerson, B A ; N'Guyen, J-P ; Pinter, M ; Pollak, P ; von Raison, F ; Rehncrona, Stig ; Speelman, J D ; Sydow, O ; Benabid, A-L. / Multicentre European study of thalamic stimulation for parkinsonian tremor: a 6 year follow-up. I: Journal of Neurology, Neurosurgery and Psychiatry. 2008 ; Vol. 79, Nr. 6. s. 694-699.

RIS

TY - JOUR

T1 - Multicentre European study of thalamic stimulation for parkinsonian tremor: a 6 year follow-up

AU - Hariz, M I

AU - Krack, P

AU - Alesch, F

AU - Augustinsson, L-E

AU - Bosch, A

AU - Ekberg, R

AU - Johansson, F

AU - Johnels, B

AU - Meyerson, B A

AU - N'Guyen, J-P

AU - Pinter, M

AU - Pollak, P

AU - von Raison, F

AU - Rehncrona, Stig

AU - Speelman, J D

AU - Sydow, O

AU - Benabid, A-L

PY - 2008

Y1 - 2008

N2 - Aim: To evaluate the results of ventral intermediate (Vim) thalamic deep brain stimulation (DBS) in patients with tremor predominant Parkinson's disease (PD) at 6 years post surgery. Methods: This was a prolonged follow-up study of 38 patients from eight centres who participated in a multicentre study, the 1 year results of which have been published previously. Total scores as well as scores for individual items of the motor part and the disability part of the Unified Parkinson's Disease Rating Scale were used for evaluation. Results: Tremor was still effectively controlled by DBS and appendicular rigidity and akinesia remained stable compared with baseline. Axial scores (speech, gait and postural instability), however, worsened, and in parallel the initial improvement in activities of daily living scores at the 1 year follow-up had disappeared at 6 years, despite sustained improvement of tremor. Remarkably, neither daily doses of dopaminergic medication nor fluctuations and dyskinesias had changed at 6 years compared with baseline in this particular patient group. Conclusion: This study confirms that patients with tremor dominant PD who do not present with fluctuations and dyskinesias may have a relatively benign progression of the disease. Vim DBS, although having no effect on akinesia and rigidity, is a relatively lenient surgical procedure and may still have a place for long term symptomatic control of PD tremor in selected patients.

AB - Aim: To evaluate the results of ventral intermediate (Vim) thalamic deep brain stimulation (DBS) in patients with tremor predominant Parkinson's disease (PD) at 6 years post surgery. Methods: This was a prolonged follow-up study of 38 patients from eight centres who participated in a multicentre study, the 1 year results of which have been published previously. Total scores as well as scores for individual items of the motor part and the disability part of the Unified Parkinson's Disease Rating Scale were used for evaluation. Results: Tremor was still effectively controlled by DBS and appendicular rigidity and akinesia remained stable compared with baseline. Axial scores (speech, gait and postural instability), however, worsened, and in parallel the initial improvement in activities of daily living scores at the 1 year follow-up had disappeared at 6 years, despite sustained improvement of tremor. Remarkably, neither daily doses of dopaminergic medication nor fluctuations and dyskinesias had changed at 6 years compared with baseline in this particular patient group. Conclusion: This study confirms that patients with tremor dominant PD who do not present with fluctuations and dyskinesias may have a relatively benign progression of the disease. Vim DBS, although having no effect on akinesia and rigidity, is a relatively lenient surgical procedure and may still have a place for long term symptomatic control of PD tremor in selected patients.

U2 - 10.1136/jnnp.2007.118653

DO - 10.1136/jnnp.2007.118653

M3 - Article

VL - 79

SP - 694

EP - 699

JO - Journal of Neurology, Neurosurgery and Psychiatry

T2 - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 1468-330X

IS - 6

ER -