Multimodal imaging to study the morphochemistry of basal cell carcinoma

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Multimodal imaging to study the morphochemistry of basal cell carcinoma. / Vogler, Nadine; Meyer, Tobias; Akimov, Denis; Latka, Ines; Krafft, Christoph; Bendsöe, Niels; Svanberg, Katarina; Dietzek, Benjamin; Popp, Juergen.

I: Journal of Biophotonics, Vol. 3, Nr. 10-11, 2010, s. 728-736.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Vogler, N, Meyer, T, Akimov, D, Latka, I, Krafft, C, Bendsöe, N, Svanberg, K, Dietzek, B & Popp, J 2010, 'Multimodal imaging to study the morphochemistry of basal cell carcinoma', Journal of Biophotonics, vol. 3, nr. 10-11, s. 728-736. https://doi.org/10.1002/jbio.201000071

APA

Vogler, N., Meyer, T., Akimov, D., Latka, I., Krafft, C., Bendsöe, N., Svanberg, K., Dietzek, B., & Popp, J. (2010). Multimodal imaging to study the morphochemistry of basal cell carcinoma. Journal of Biophotonics, 3(10-11), 728-736. https://doi.org/10.1002/jbio.201000071

CBE

MLA

Vancouver

Author

Vogler, Nadine ; Meyer, Tobias ; Akimov, Denis ; Latka, Ines ; Krafft, Christoph ; Bendsöe, Niels ; Svanberg, Katarina ; Dietzek, Benjamin ; Popp, Juergen. / Multimodal imaging to study the morphochemistry of basal cell carcinoma. I: Journal of Biophotonics. 2010 ; Vol. 3, Nr. 10-11. s. 728-736.

RIS

TY - JOUR

T1 - Multimodal imaging to study the morphochemistry of basal cell carcinoma

AU - Vogler, Nadine

AU - Meyer, Tobias

AU - Akimov, Denis

AU - Latka, Ines

AU - Krafft, Christoph

AU - Bendsöe, Niels

AU - Svanberg, Katarina

AU - Dietzek, Benjamin

AU - Popp, Juergen

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Atomic physics (011013005), Department of Dermatology and Venerology (013241320), Oncology, MV (013035000), Department of Dermatology and Venereology (Lund) (013006000)

PY - 2010

Y1 - 2010

N2 - Basal cell carcinoma is the most abundant malignant neoplasm in humans, the pathology of which is characterized by an abnormal proliferation of basal cells. Basal cell carcinoma can show a variety of different morphologies, which are based on different cellular biology. Furthermore, the carcinoma often grows invisibly to the eye imbedded in the surrounding skin. Therefore, in some cases its clinical detection is challenging. Thus, our work aims at establishing an unsupervised tissue classification method based on multimodal imaging and the application of chemometrics to discriminate basal cell carcinoma from non-diseased tissue. A case study applying multimodal imaging to ex-vivo sections of basal cell carcinoma is presented. In doing so, we apply a combination of various linear and non-linear imaging modalities, i.e. fluorescence, Raman and second-harmonic generation microscopy, to study the morphochemistry of basal cell carcinoma. The joint information content obtained by such multimodal approach in studying various aspects of the malignant tissue alterations associated with basal cell carcinoma is discussed. [GRAPHICS] Multimodal imaging combining coherent anti-Stokes Raman scattering, second-harmonic generation and two-photo fluorescence is combined with Raman spectroscopy to investigate the morphochemistry of human basal cell carcinoma.

AB - Basal cell carcinoma is the most abundant malignant neoplasm in humans, the pathology of which is characterized by an abnormal proliferation of basal cells. Basal cell carcinoma can show a variety of different morphologies, which are based on different cellular biology. Furthermore, the carcinoma often grows invisibly to the eye imbedded in the surrounding skin. Therefore, in some cases its clinical detection is challenging. Thus, our work aims at establishing an unsupervised tissue classification method based on multimodal imaging and the application of chemometrics to discriminate basal cell carcinoma from non-diseased tissue. A case study applying multimodal imaging to ex-vivo sections of basal cell carcinoma is presented. In doing so, we apply a combination of various linear and non-linear imaging modalities, i.e. fluorescence, Raman and second-harmonic generation microscopy, to study the morphochemistry of basal cell carcinoma. The joint information content obtained by such multimodal approach in studying various aspects of the malignant tissue alterations associated with basal cell carcinoma is discussed. [GRAPHICS] Multimodal imaging combining coherent anti-Stokes Raman scattering, second-harmonic generation and two-photo fluorescence is combined with Raman spectroscopy to investigate the morphochemistry of human basal cell carcinoma.

U2 - 10.1002/jbio.201000071

DO - 10.1002/jbio.201000071

M3 - Article

C2 - 20648521

VL - 3

SP - 728

EP - 736

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 10-11

ER -