Multispectral guided fluorescence diffuse optical tomography using upconverting nanoparticles

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

We report on improved image detectability for fluorescence diffuse optical tomography using upconverting nanoparticles doped with rare-earth elements. Core-shell NaYF4 : Yb3+/Er3+ @ NaYF4 upconverting nanoparticles were synthesized through a stoichiometric method. The Yb3+/Er3+ sensitizer-activator pair yielded two anti-Stokes shifted fluorescence emission bands at 540 nm and 660 nm, here used to a priori estimate the fluorescence source depth with sub-millimeter precision. A spatially varying regularization incorporated the a priori fluorescence source depth estimation into the tomography reconstruction scheme. Tissue phantom experiments showed both an improved resolution and contrast in the reconstructed images as compared to not using any a priori information. (C) 2014 AIP Publishing LLC.

Detaljer

Författare
  • Pontus Svenmarker
  • Can Xu
  • Haichun Liu
  • Xia Wu
  • Stefan Andersson-Engels
Enheter & grupper
Externa organisationer
  • Umeå University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Atom- och molekylfysik och optik
Originalspråkengelska
Artikelnummer073703
TidskriftApplied Physics Letters
Volym104
Utgåva nummer7
StatusPublished - 2014
PublikationskategoriForskning
Peer review utfördJa