Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Ribosomal protein S19 (RP S19) possesses ribosomal function as RP S19 monomer and extraribosomal function as cross-linked RP S19 oligomers which function as a ligand of the complement 5a (C5a) receptor (CD88). We have generated a Gln137Glu-RP S19 knock-in (KI) mouse, which is shown to possess the weakened extraribosomal function of RP S19. Because whether the extraribosomal function of RP S19 has a role in brain function had been unclear, we performed behavioral analysis on these mice and demonstrated that KI mice displayed an increased grooming behavior during open-field test and elevated plus maze test and an enhanced freezing behavior in contextual fear conditioning test. These results suggest an involvement of RP S19 oligomers in some anxiety-like behavior, especially grooming behavior.

Detaljer

Författare
  • Jun Chen
  • Taku Kaitsuka
  • Rika Fujino
  • Kimi Araki
  • Kazuhito Tomizawa
  • Tetsuro Yamamoto
Enheter & grupper
Externa organisationer
  • Kumamoto University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)221-226
Antal sidor6
TidskriftNeuroscience Letters
Volym629
StatusPublished - 2016 aug 26
PublikationskategoriForskning
Peer review utfördJa