MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The MYC genes are the most frequently activated oncogenes in human tumors and are hence attractive therapeutic targets. MYCN amplification leads to poor clinical outcome in childhood neuroblastoma, yet strategies to modulate the function of MYCN do not exist. Here we show that 10058-F4, a characterized c-MYC/Max inhibitor, also targets the MYCN/Max interaction, leading to cell cycle arrest, apoptosis, and neuronal differentiation in MYCN-amplified neuroblastoma cells and to increased survival of MYCN transgenic mice. We also report the discovery that inhibition of MYC is accompanied by accumulation of intracellular lipid droplets in tumor cells as a direct consequence of mitochondrial dysfunction. This study expands on the current knowledge of how MYC proteins control the metabolic reprogramming of cancer cells, especially highlighting lipid metabolism and the respiratory chain as important pathways involved in neuroblastoma pathogenesis. Together our data support direct MYC inhibition as a promising strategy for the treatment of MYC-driven tumors.

Detaljer

Författare
  • Hanna Zirath
  • Anna Frenzel
  • Ganna Oliynyk
  • Lova Segerstrom
  • Ulrica K. Westermark
  • Karin Larsson
  • Matilda Thorén
  • Kjell Hultenby
  • Janne Lehtio
  • Christer Einvik
  • Sven Påhlman
  • Per Kogner
  • Per-Johan Jakobsson
  • Marie Arsenian Henriksson
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi

Nyckelord

Originalspråkengelska
Sidor (från-till)10258-10263
TidskriftProceedings of the National Academy of Sciences
Volym110
Utgivningsnummer25
StatusPublished - 2013
PublikationskategoriForskning
Peer review utfördJa