Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceeding

Abstract

Aβ is a class of aggregation-prone proteins, which may misfold into stable, β-sheet rich fibrils. Aβ is linked to the development of synaptic pathology in Alzheimer's disease (AD). However, a main question in the AD field is how Aβ contributes to AD neuropathology? Up to now there is little evidence for protein structural changes in diseased neuron. Our aim is to study the distribution of β-sheet structures in AD transgenic neurons in order to uncover sub-cellular mechanism(s) by which amyloid β-sheet structures are involved in AD pathology.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • University of Paris-Sud
  • Brookhaven National Laboratory
  • Brazilian Synchroton Light Laboratory
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper
  • Medicinsk bildbehandling
Originalspråkengelska
Titel på värdpublikation2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018
FörlagIEEE Computer Society
Volym2018-September
ISBN (elektroniskt)9781538638095
StatusPublished - 2018 okt 29
PublikationskategoriForskning
Peer review utfördJa
Evenemang43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018 - Nagoya, Japan
Varaktighet: 2018 sep 92018 sep 14

Konferens

Konferens43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018
LandJapan
OrtNagoya
Period2018/09/092018/09/14