Nanostructured Lipid-Based Films for Substrate-Mediated Applications in Biotechnology

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Nanostructured Lipid-Based Films for Substrate-Mediated Applications in Biotechnology. / Kang, Minjee; Tuteja, Mohit; Centrone, Andrea; Topgaard, Daniel; Leal, Cecilia.

I: Advanced Functional Materials, Vol. 28, Nr. 9, 1704356, 2018.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Kang, Minjee ; Tuteja, Mohit ; Centrone, Andrea ; Topgaard, Daniel ; Leal, Cecilia. / Nanostructured Lipid-Based Films for Substrate-Mediated Applications in Biotechnology. I: Advanced Functional Materials. 2018 ; Vol. 28, Nr. 9.

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TY - JOUR

T1 - Nanostructured Lipid-Based Films for Substrate-Mediated Applications in Biotechnology

AU - Kang, Minjee

AU - Tuteja, Mohit

AU - Centrone, Andrea

AU - Topgaard, Daniel

AU - Leal, Cecilia

PY - 2018

Y1 - 2018

N2 - Amphiphilic in nature, lipids spontaneously self-assemble into a range of nanostructures in the presence of water. Among lipid self-assembled structures, liposomes and supported lipid bilayers have long held scientific interest for their main applications in drug delivery and plasma membrane models, respectively. In contrast, lipid-based multilayered membranes on solid supports only recently begin drawing scientists' attention. Current studies show that the stacking of multiple bilayers on a solid support yields cooperative structural and dynamic behavior that enables new functionalities. Lipid films provide compartmentalization, templating, and enhanced release of molecules of interest. Importantly, supported lipid phases exhibit long-range periodic nanoscale order and orientation that is tunable in response to a changing environment. Herein, the current understanding of lipid-based film research is summarized focusing on how unique structural characteristics enable the emergence of new applications including label-free biosensors, macroscale drug delivery, and substrate-mediated gene delivery. The authors' recent contributions focusing on the structural characterization of lipid-based films using small-angle X-ray scattering and atomic force microscopy are highlighted. In addition, new photothermally induced resonance and solid-state nuclear magnetic resonance data are described, providing insights into drug partition in lipid-based films as well as structure and dynamics at the molecular scale.

AB - Amphiphilic in nature, lipids spontaneously self-assemble into a range of nanostructures in the presence of water. Among lipid self-assembled structures, liposomes and supported lipid bilayers have long held scientific interest for their main applications in drug delivery and plasma membrane models, respectively. In contrast, lipid-based multilayered membranes on solid supports only recently begin drawing scientists' attention. Current studies show that the stacking of multiple bilayers on a solid support yields cooperative structural and dynamic behavior that enables new functionalities. Lipid films provide compartmentalization, templating, and enhanced release of molecules of interest. Importantly, supported lipid phases exhibit long-range periodic nanoscale order and orientation that is tunable in response to a changing environment. Herein, the current understanding of lipid-based film research is summarized focusing on how unique structural characteristics enable the emergence of new applications including label-free biosensors, macroscale drug delivery, and substrate-mediated gene delivery. The authors' recent contributions focusing on the structural characterization of lipid-based films using small-angle X-ray scattering and atomic force microscopy are highlighted. In addition, new photothermally induced resonance and solid-state nuclear magnetic resonance data are described, providing insights into drug partition in lipid-based films as well as structure and dynamics at the molecular scale.

KW - Lipid films

KW - Lipid-polymer hybrids

KW - Solid-state NMR

KW - Substrate-mediated delivery

KW - Supported membranes

U2 - 10.1002/adfm.201704356

DO - 10.1002/adfm.201704356

M3 - Article

VL - 28

JO - Advanced Functional Materials

JF - Advanced Functional Materials

SN - 1616-3028

IS - 9

M1 - 1704356

ER -