Nanotubes and bilayers in a model peptide system

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


The trifluoroacetate (tfa) salt of the peptide (ala)(6)lys self-assembles in water into very long, hollow nanotubes with a radius R = 26 nm, above a critical aggregation concentration (volume fraction), phi(cac) = 0.10. The peptides carry a net positive charge that ensures colloidal stability of the self-assembly structures through a long-range electrostatic repulsion. There is only a weak temperature dependence of phi(cac) from which an enthalpy of aggregation of -k(B)T per molecule is estimated. SAXS data show that the thickness of the nanotube wall, delta, is less than 1 nm indicating that the peptides form a monolayer in the nanotube wall. The nanotubes have a very large aspect ratio and form an ordered nematic or hexagonal phase. Because of the low delta/R ratio, the nanotube volume fraction grows very rapidly with increasing peptide concentration, phi, and reaches close packing already at phi = 0.15. When increasing the concentration further, there is a phase transition to a novel lamellar phase where the peptide molecules form bilayers consisting of two, presumably oppositely oriented, monolayers.


Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Fysikalisk kemi
Sidor (från-till)4868-4875
TidskriftSoft Matter
Utgåva nummer10
StatusPublished - 2011
Peer review utfördJa