Neurologic disorders in long-term survivors of neuroblastoma–a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) research program

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Bibtex

@article{b4436062322448da8cd7f0b981c48dbc,
title = "Neurologic disorders in long-term survivors of neuroblastoma–a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) research program",
abstract = "Background: Neuroblastoma is the commonest extracranial solid tumor of childhood, yet rare, and with poor survival before 1990, especially for high-risk disease; thus, information on late effects is sparse. With great advances in cancer treatment, survival has reached 80% in the Nordic countries. The aim of the study was to investigate the risk of developing neurologic disorders after neuroblastoma. Material and methods: Through population-based cancer registries of four Nordic countries we identified 654 5-year survivors of neuroblastoma (diagnosed 1959–2008) and 133,668 matched population comparisons. We grouped neurologic diagnoses from national hospital registries into 11 main diagnostic categories and 56 disease-specific sub-categories and calculated relative risks (RRs), absolute excess risks (AERs), cumulative incidence and mean cumulative count (MCC). Information on cancer treatment was available for 49% of survivors. Results: A hospital contact for a neurologic disorder was observed in 181 survivors 5 years or more from cancer diagnosis with 59 expected, yielding a RR of 3.1 (95% CI 2.7–3.6) and an AER of 16 per 1,000 person-years (95% CI 12–19). The most frequent disorders included epilepsy, paralytic syndromes, diseases of the eyes and ears and hearing loss. The cumulative incidence of any neurologic disorder was 31% in survivors 20 years after cancer diagnosis with a MCC of 0.5 unique diagnoses. All risks were highest in survivors of high-risk neuroblastoma. Conclusion: Neuroblastoma survivors represent a population with a high risk of developing neurologic disorders. Our results should contribute to improving health care planning and underscores the need for systematic follow-up care of this vulnerable group of survivors.",
author = "Norsker, {Filippa Nyboe} and Catherine Rechnitzer and Andersen, {Elisabeth Wreford} and Linnet, {Karen Markussen} and Line Kenborg and Holmqvist, {Anna S{\"a}llfors} and Laufey Tryggvadottir and Madanat-Harjuoja, {Laura Maria} and Ingrid {\O}ra and Thorarinsdottir, {Halldora K.} and Kim Vettenranta and Andrea Bautz and Henrik Schr{\o}der and Henrik Hasle and Winther, {Jeanette Falck}",
year = "2020",
doi = "10.1080/0284186X.2019.1672892",
language = "English",
volume = "59",
pages = "134--140",
journal = "Acta Oncologica",
issn = "1651-226X",
publisher = "Taylor & Francis",
number = "2",

}