Neuropeptide Y: prejunctional inhibition of vagally induced contractions in the guinea pig trachea

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Abstract

The effects of neuropeptide Y (NPY) on the contractile response to vagus nerve stimulation at different frequencies was studied in an isolated tracheal tube preparation from guinea pig. NPY had no effect on basal smooth muscle tension or on the contractile effect of carbachol, but inhibited vagally induced contractions in a concentration-dependent manner with a greater inhibition at low frequencies than at high. We suggest that the effect is exerted prejunctionally.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Astra Draco AB
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Farmakologi och toxikologi

Nyckelord

Originalspråkengelska
Sidor (från-till)309-313
TidskriftRegulatory Peptides
Volym23
Utgåva nummer3
StatusPublished - 1988 dec
PublikationskategoriForskning
Peer review utfördJa