Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Here, we characterize a subset of ILC3s that express Neuropilin1 (NRP1) and are present in lymphoid tissues, but not in the peripheral blood or skin. NRP1+ group 3 innate lymphoid cells (ILC3s) display in vitro lymphoid tissue inducer (LTi) activity. In agreement with this, NRP1+ ILC3s are mainly located in proximity to high endothelial venules (HEVs) and express cell surface molecules involved in lymphocyte migration in secondary lymphoid tissues via HEVs. NRP1 was also expressed on mouse fetal LTi cells, indicating that NRP1 is a conserved marker for LTi cells. Human NRP1+ ILC3s are primed cells because they express CD45RO and produce higher amounts of cytokines than NRP1 cells, which express CD45RA. The NRP1 ligand vascular endothelial growth factor A (VEGF-A) served as a chemotactic factor for NRP1+ ILC3s. NRP1+ ILC3s are present in lung tissues from smokers and patients with chronic obstructive pulmonary disease, suggesting a role in angiogenesis and/or the initiation of ectopic pulmonary lymphoid aggregates.

Detaljer

Författare
  • Medya Mara Shikhagaie
  • Åsa K. Björklund
  • Jenny Mjösberg
  • Jonas S. Erjefält
  • Anne S. Cornelissen
  • Xavier Romero Ros
  • Suzanne M. Bal
  • Jasper J. Koning
  • Reina E. Mebius
  • Michiko Mori
  • Melanie Bruchard
  • Bianca Blom
  • Hergen Spits
Enheter & grupper
Externa organisationer
  • University of Amsterdam
  • Karolinska Institute
  • Vrije Universiteit Amsterdam
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cell- och molekylärbiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)1761-1773
Antal sidor13
TidskriftCell Reports
Volym18
Utgivningsnummer7
StatusPublished - 2017 feb 14
PublikationskategoriForskning
Peer review utfördJa