Neutrophil extracellular traps - The dark side of neutrophils

Forskningsoutput: TidskriftsbidragÖversiktsartikel


Neutrophil extracellular traps (NETs) were discovered as extracellular strands of decondensed DNA in complex with histones and granule proteins, which were expelled from dying neutrophils to ensnare and kill microbes. NETs are formed during infection in vivo by mechanisms different from those originally described in vitro. Citrullination of histones by peptidyl arginine deiminase 4 (PAD4) is central for NET formation in vivo. NETs may spur formation of autoantibodies and may also serve as scaffolds for thrombosis, thereby providing a link among infection, autoimmunity, and thrombosis. In this review, we present the mechanisms by which NETs are formed and discuss the physiological and pathophysiological consequences of NET formation. We conclude that NETs may be of more importance in autoimmunity and thrombosis than in innate immune defense.


Enheter & grupper
Externa organisationer
  • University of Copenhagen

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Infektionsmedicin
Sidor (från-till)1612-1620
Antal sidor9
TidskriftJournal of Clinical Investigation
StatusPublished - 2016 maj 2
Peer review utfördJa