New approaches for brain repair-from rescue to reprogramming

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New approaches using stem-cell-derived cell products and direct cell reprogramming have opened up the possibility of reconstructing neural circuits and achieving better repair. In this Review we briefly summarize the history of neural repair and then discuss these new therapeutic approaches, especially with respect to chronic neurodegenerative disorders.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • University of Cambridge
  • Ludwig-Maximilian University of Munich
  • Munich Cluster for Systems Neurology
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi

Nyckelord

Originalspråkengelska
Sidor (från-till)329-334
TidskriftNature
Volym557
Utgivningsnummer7705
StatusPublished - 2018 maj
PublikationskategoriForskning
Peer review utfördJa