New genetic loci link adipose and insulin biology to body fat distribution.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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New genetic loci link adipose and insulin biology to body fat distribution. / Shungin, Dmitry; Winkler, Thomas W; Croteau-Chonka, Damien C; Ferreira, Teresa; Locke, Adam E; Mägi, Reedik; Strawbridge, Rona J; Pers, Tune H; Fischer, Krista; Justice, Anne E; Workalemahu, Tsegaselassie; Wu, Joseph M W; Buchkovich, Martin L; Heard-Costa, Nancy L; Roman, Tamara S; Drong, Alexander W; Song, Ci; Gustafsson, Stefan; Day, Felix R; Esko, Tonu; Fall, Tove; Kutalik, Zoltán; Luan, Jian'an; Randall, Joshua C; Scherag, André; Vedantam, Sailaja; Wood, Andrew R; Chen, Jin; Fehrmann, Rudolf; Karjalainen, Juha; Kahali, Bratati; Liu, Ching-Ti; Schmidt, Ellen M; Absher, Devin; Amin, Najaf; Anderson, Denise; Beekman, Marian; Bragg-Gresham, Jennifer L; Buyske, Steven; Demirkan, Ayse; Ehret, Georg B; Feitosa, Mary F; Goel, Anuj; Jackson, Anne U; Johnson, Toby; Kleber, Marcus E; Kristiansson, Kati; Mangino, Massimo; Mateo Leach, Irene; Medina-Gomez, Carolina; Palmer, Cameron D; Pasko, Dorota; Pechlivanis, Sonali; Peters, Marjolein J; Prokopenko, Inga; Stančáková, Alena; Ju Sung, Yun; Tanaka, Toshiko; Teumer, Alexander; Van Vliet-Ostaptchouk, Jana V; Yengo, Loïc; Zhang, Weihua; Albrecht, Eva; Ärnlöv, Johan; Arscott, Gillian M; Bandinelli, Stefania; Barrett, Amy; Bellis, Claire; Bennett, Amanda J; Berne, Christian; Blüher, Matthias; Böhringer, Stefan; Bonnet, Fabrice; Böttcher, Yvonne; Bruinenberg, Marcel; Carba, Delia B; Caspersen, Ida H; Clarke, Robert; Daw, E Warwick; Deelen, Joris; Deelman, Ewa; Delgado, Graciela; Doney, Alex S F; Eklund, Niina; Erdos, Michael R; Estrada, Karol; Eury, Elodie; Friedrich, Nele; Garcia, Melissa E; Giedraitis, Vilmantas; Gigante, Bruna; Go, Alan S; Golay, Alain; Grallert, Harald; Grammer, Tanja B; Gräßler, Jürgen; Grewal, Jagvir; Groves, Christopher J; Haller, Toomas; Hallmans, Goran; Hartman, Catharina A; Hassinen, Maija; Hayward, Caroline; Heikkilä, Kauko; Herzig, Karl-Heinz; Helmer, Quinta; Hillege, Hans L; Holmen, Oddgeir; Hunt, Steven C; Isaacs, Aaron; Ittermann, Till; James, Alan L; Johansson, Ingegerd; Juliusdottir, Thorhildur; Kalafati, Ioanna-Panagiota; Kinnunen, Leena; Koenig, Wolfgang; Kooner, Ishminder K; Kratzer, Wolfgang; Lamina, Claudia; Leander, Karin; Lee, Nanette R; Lichtner, Peter; Lind, Lars; Lindström, Jaana; Lobbens, Stéphane; Lorentzon, Mattias; Mach, François; Magnusson, Patrik K E; Mahajan, Anubha; McArdle, Wendy L; Menni, Cristina; Merger, Sigrun; Mihailov, Evelin; Milani, Lili; Mills, Rebecca; Moayyeri, Alireza; Monda, Keri L; Mooijaart, Simon P; Mühleisen, Thomas W; Mulas, Antonella; Müller, Gabriele; Müller-Nurasyid, Martina; Nagaraja, Ramaiah; Nalls, Michael A; Narisu, Narisu; Glorioso, Nicola; Nolte, Ilja M; Olden, Matthias; Rayner, Nigel W; Renström, Frida; Ried, Janina S; Robertson, Neil R; Rose, Lynda M; Sanna, Serena; Scharnagl, Hubert; Scholtens, Salome; Sennblad, Bengt; Seufferlein, Thomas; Sitlani, Colleen M; Vernon Smith, Albert; Stirrups, Kathleen; Stringham, Heather M; Sundström, Johan; Swertz, Morris A; Swift, Amy J; Syvänen, Ann-Christine; Tayo, Bamidele O; Thorand, Barbara; Thorleifsson, Gudmar; Tomaschitz, Andreas; Troffa, Chiara; van Oort, Floor V A; Verweij, Niek; Vonk, Judith M; Waite, Lindsay L; Wennauer, Roman; Wilsgaard, Tom; Wojczynski, Mary K; Wong, Andrew; Zhang, Qunyuan; Hua Zhao, Jing; Brennan, Eoin P; Choi, Murim; Eriksson, Per; Folkersen, Lasse; Franco-Cereceda, Anders; Gharavi, Ali G; Hedman, Åsa K; Hivert, Marie-France; Huang, Jinyan; Kanoni, Stavroula; Karpe, Fredrik; Keildson, Sarah; Kiryluk, Krzysztof; Liang, Liming; Lifton, Richard P; Ma, Baoshan; McKnight, Amy J; McPherson, Ruth; Metspalu, Andres; Min, Josine L; Moffatt, Miriam F; Montgomery, Grant W; Murabito, Joanne M; Nicholson, George; Nyholt, Dale R; Olsson, Christian; Perry, John R B; Reinmaa, Eva; Salem, Rany M; Sandholm, Niina; Schadt, Eric E; Scott, Robert A; Stolk, Lisette; Vallejo, Edgar E; Westra, Harm-Jan; Zondervan, Krina T; Amouyel, Philippe; Arveiler, Dominique; Bakker, Stephan J L; Beilby, John; Bergman, Richard N; Blangero, John; Brown, Morris J; Burnier, Michel; Campbell, Harry; Chakravarti, Aravinda; Chines, Peter S; Claudi-Boehm, Simone; Collins, Francis S; Crawford, Dana C; Danesh, John; de Faire, Ulf; de Geus, Eco J C; Dörr, Marcus; Erbel, Raimund; Eriksson, Johan G; Farrall, Martin; Ferrannini, Ele; Ferrières, Jean; Forouhi, Nita G; Forrester, Terrence; Franco, Oscar H; Gansevoort, Ron T; Gieger, Christian; Gudnason, Vilmundur; Haiman, Christopher A; Harris, Tamara B; Hattersley, Andrew T; Heliövaara, Markku; Hicks, Andrew A; Hingorani, Aroon D; Hoffmann, Wolfgang; Hofman, Albert; Homuth, Georg; Humphries, Steve E; Hyppönen, Elina; Illig, Thomas; Jarvelin, Marjo-Riitta; Johansen, Berit; Jousilahti, Pekka; Jula, Antti M; Kaprio, Jaakko; Kee, Frank; Keinanen-Kiukaanniemi, Sirkka M; Kooner, Jaspal S; Kooperberg, Charles; Kovacs, Peter; Kraja, Aldi T; Kumari, Meena; Kuulasmaa, Kari; Kuusisto, Johanna; Lakka, Timo A; Langenberg, Claudia; Le Marchand, Loic; Lehtimäki, Terho; Lyssenko, Valeriya; Männistö, Satu; Marette, André; Matise, Tara C; McKenzie, Colin A; McKnight, Barbara; Musk, Arthur W; Möhlenkamp, Stefan; Morris, Andrew D; Nelis, Mari; Ohlsson, Claes; Oldehinkel, Albertine J; Ong, Ken K; Palmer, Lyle J; Penninx, Brenda W; Peters, Annette; Pramstaller, Peter P; Raitakari, Olli T; Rankinen, Tuomo; Rao, D C; Rice, Treva K; Ridker, Paul M; Ritchie, Marylyn D; Rudan, Igor; Salomaa, Veikko; Samani, Nilesh J; Saramies, Jouko; Sarzynski, Mark A; Schwarz, Peter E H; Shuldiner, Alan R; Staessen, Jan A; Steinthorsdottir, Valgerdur; Stolk, Ronald P; Strauch, Konstantin; Tönjes, Anke; Tremblay, Angelo; Tremoli, Elena; Vohl, Marie-Claude; Völker, Uwe; Vollenweider, Peter; Wilson, James F; Witteman, Jacqueline C; Adair, Linda S; Bochud, Murielle; Boehm, Bernhard O; Bornstein, Stefan R; Bouchard, Claude; Cauchi, Stéphane; Caulfield, Mark J; Chambers, John C; Chasman, Daniel I; Cooper, Richard S; Dedoussis, George; Ferrucci, Luigi; Froguel, Philippe; Grabe, Hans-Jörgen; Hamsten, Anders; Hui, Jennie; Hveem, Kristian; Jöckel, Karl-Heinz; Kivimaki, Mika; Kuh, Diana; Laakso, Markku; Liu, Yongmei; März, Winfried; Munroe, Patricia B; Njølstad, Inger; Oostra, Ben A; Palmer, Colin N A; Pedersen, Nancy L; Perola, Markus; Pérusse, Louis; Peters, Ulrike; Power, Chris; Quertermous, Thomas; Rauramaa, Rainer; Rivadeneira, Fernando; Saaristo, Timo E; Saleheen, Danish; Sinisalo, Juha; Slagboom, P Eline; Snieder, Harold; Spector, Tim D; Thorsteinsdottir, Unnur; Stumvoll, Michael; Tuomilehto, Jaakko; Uitterlinden, André G; Uusitupa, Matti; van der Harst, Pim; Veronesi, Giovanni; Walker, Mark; Wareham, Nicholas J; Watkins, Hugh; Wichmann, H-Erich; Abecasis, Goncalo R; Assimes, Themistocles L; Berndt, Sonja I; Boehnke, Michael; Borecki, Ingrid B; Deloukas, Panos; Franke, Lude; Frayling, Timothy M; Groop, Leif; Hunter, David J; Kaplan, Robert C; O'Connell, Jeffrey R; Qi, Lu; Schlessinger, David; Strachan, David P; Stefansson, Kari; van Duijn, Cornelia M; Willer, Cristen J; Visscher, Peter M; Yang, Jian; Hirschhorn, Joel N; Zillikens, M Carola; McCarthy, Mark I; Speliotes, Elizabeth K; North, Kari E; Fox, Caroline S; Barroso, Inês; Franks, Paul W; Ingelsson, Erik; Heid, Iris M; Loos, Ruth J F; Cupples, L Adrienne; Morris, Andrew P; Lindgren, Cecilia M; Mohlke, Karen L.

I: Nature, Vol. 518, Nr. 7538, 2015, s. 187-U378.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Shungin, D, Winkler, TW, Croteau-Chonka, DC, Ferreira, T, Locke, AE, Mägi, R, Strawbridge, RJ, Pers, TH, Fischer, K, Justice, AE, Workalemahu, T, Wu, JMW, Buchkovich, ML, Heard-Costa, NL, Roman, TS, Drong, AW, Song, C, Gustafsson, S, Day, FR, Esko, T, Fall, T, Kutalik, Z, Luan, J, Randall, JC, Scherag, A, Vedantam, S, Wood, AR, Chen, J, Fehrmann, R, Karjalainen, J, Kahali, B, Liu, C-T, Schmidt, EM, Absher, D, Amin, N, Anderson, D, Beekman, M, Bragg-Gresham, JL, Buyske, S, Demirkan, A, Ehret, GB, Feitosa, MF, Goel, A, Jackson, AU, Johnson, T, Kleber, ME, Kristiansson, K, Mangino, M, Mateo Leach, I, Medina-Gomez, C, Palmer, CD, Pasko, D, Pechlivanis, S, Peters, MJ, Prokopenko, I, Stančáková, A, Ju Sung, Y, Tanaka, T, Teumer, A, Van Vliet-Ostaptchouk, JV, Yengo, L, Zhang, W, Albrecht, E, Ärnlöv, J, Arscott, GM, Bandinelli, S, Barrett, A, Bellis, C, Bennett, AJ, Berne, C, Blüher, M, Böhringer, S, Bonnet, F, Böttcher, Y, Bruinenberg, M, Carba, DB, Caspersen, IH, Clarke, R, Daw, EW, Deelen, J, Deelman, E, Delgado, G, Doney, ASF, Eklund, N, Erdos, MR, Estrada, K, Eury, E, Friedrich, N, Garcia, ME, Giedraitis, V, Gigante, B, Go, AS, Golay, A, Grallert, H, Grammer, TB, Gräßler, J, Grewal, J, Groves, CJ, Haller, T, Hallmans, G, Hartman, CA, Hassinen, M, Hayward, C, Heikkilä, K, Herzig, K-H, Helmer, Q, Hillege, HL, Holmen, O, Hunt, SC, Isaacs, A, Ittermann, T, James, AL, Johansson, I, Juliusdottir, T, Kalafati, I-P, Kinnunen, L, Koenig, W, Kooner, IK, Kratzer, W, Lamina, C, Leander, K, Lee, NR, Lichtner, P, Lind, L, Lindström, J, Lobbens, S, Lorentzon, M, Mach, F, Magnusson, PKE, Mahajan, A, McArdle, WL, Menni, C, Merger, S, Mihailov, E, Milani, L, Mills, R, Moayyeri, A, Monda, KL, Mooijaart, SP, Mühleisen, TW, Mulas, A, Müller, G, Müller-Nurasyid, M, Nagaraja, R, Nalls, MA, Narisu, N, Glorioso, N, Nolte, IM, Olden, M, Rayner, NW, Renström, F, Ried, JS, Robertson, NR, Rose, LM, Sanna, S, Scharnagl, H, Scholtens, S, Sennblad, B, Seufferlein, T, Sitlani, CM, Vernon Smith, A, Stirrups, K, Stringham, HM, Sundström, J, Swertz, MA, Swift, AJ, Syvänen, A-C, Tayo, BO, Thorand, B, Thorleifsson, G, Tomaschitz, A, Troffa, C, van Oort, FVA, Verweij, N, Vonk, JM, Waite, LL, Wennauer, R, Wilsgaard, T, Wojczynski, MK, Wong, A, Zhang, Q, Hua Zhao, J, Brennan, EP, Choi, M, Eriksson, P, Folkersen, L, Franco-Cereceda, A, Gharavi, AG, Hedman, ÅK, Hivert, M-F, Huang, J, Kanoni, S, Karpe, F, Keildson, S, Kiryluk, K, Liang, L, Lifton, RP, Ma, B, McKnight, AJ, McPherson, R, Metspalu, A, Min, JL, Moffatt, MF, Montgomery, GW, Murabito, JM, Nicholson, G, Nyholt, DR, Olsson, C, Perry, JRB, Reinmaa, E, Salem, RM, Sandholm, N, Schadt, EE, Scott, RA, Stolk, L, Vallejo, EE, Westra, H-J, Zondervan, KT, Amouyel, P, Arveiler, D, Bakker, SJL, Beilby, J, Bergman, RN, Blangero, J, Brown, MJ, Burnier, M, Campbell, H, Chakravarti, A, Chines, PS, Claudi-Boehm, S, Collins, FS, Crawford, DC, Danesh, J, de Faire, U, de Geus, EJC, Dörr, M, Erbel, R, Eriksson, JG, Farrall, M, Ferrannini, E, Ferrières, J, Forouhi, NG, Forrester, T, Franco, OH, Gansevoort, RT, Gieger, C, Gudnason, V, Haiman, CA, Harris, TB, Hattersley, AT, Heliövaara, M, Hicks, AA, Hingorani, AD, Hoffmann, W, Hofman, A, Homuth, G, Humphries, SE, Hyppönen, E, Illig, T, Jarvelin, M-R, Johansen, B, Jousilahti, P, Jula, AM, Kaprio, J, Kee, F, Keinanen-Kiukaanniemi, SM, Kooner, JS, Kooperberg, C, Kovacs, P, Kraja, AT, Kumari, M, Kuulasmaa, K, Kuusisto, J, Lakka, TA, Langenberg, C, Le Marchand, L, Lehtimäki, T, Lyssenko, V, Männistö, S, Marette, A, Matise, TC, McKenzie, CA, McKnight, B, Musk, AW, Möhlenkamp, S, Morris, AD, Nelis, M, Ohlsson, C, Oldehinkel, AJ, Ong, KK, Palmer, LJ, Penninx, BW, Peters, A, Pramstaller, PP, Raitakari, OT, Rankinen, T, Rao, DC, Rice, TK, Ridker, PM, Ritchie, MD, Rudan, I, Salomaa, V, Samani, NJ, Saramies, J, Sarzynski, MA, Schwarz, PEH, Shuldiner, AR, Staessen, JA, Steinthorsdottir, V, Stolk, RP, Strauch, K, Tönjes, A, Tremblay, A, Tremoli, E, Vohl, M-C, Völker, U, Vollenweider, P, Wilson, JF, Witteman, JC, Adair, LS, Bochud, M, Boehm, BO, Bornstein, SR, Bouchard, C, Cauchi, S, Caulfield, MJ, Chambers, JC, Chasman, DI, Cooper, RS, Dedoussis, G, Ferrucci, L, Froguel, P, Grabe, H-J, Hamsten, A, Hui, J, Hveem, K, Jöckel, K-H, Kivimaki, M, Kuh, D, Laakso, M, Liu, Y, März, W, Munroe, PB, Njølstad, I, Oostra, BA, Palmer, CNA, Pedersen, NL, Perola, M, Pérusse, L, Peters, U, Power, C, Quertermous, T, Rauramaa, R, Rivadeneira, F, Saaristo, TE, Saleheen, D, Sinisalo, J, Slagboom, PE, Snieder, H, Spector, TD, Thorsteinsdottir, U, Stumvoll, M, Tuomilehto, J, Uitterlinden, AG, Uusitupa, M, van der Harst, P, Veronesi, G, Walker, M, Wareham, NJ, Watkins, H, Wichmann, H-E, Abecasis, GR, Assimes, TL, Berndt, SI, Boehnke, M, Borecki, IB, Deloukas, P, Franke, L, Frayling, TM, Groop, L, Hunter, DJ, Kaplan, RC, O'Connell, JR, Qi, L, Schlessinger, D, Strachan, DP, Stefansson, K, van Duijn, CM, Willer, CJ, Visscher, PM, Yang, J, Hirschhorn, JN, Zillikens, MC, McCarthy, MI, Speliotes, EK, North, KE, Fox, CS, Barroso, I, Franks, PW, Ingelsson, E, Heid, IM, Loos, RJF, Cupples, LA, Morris, AP, Lindgren, CM & Mohlke, KL 2015, 'New genetic loci link adipose and insulin biology to body fat distribution.', Nature, vol. 518, nr. 7538, s. 187-U378. https://doi.org/10.1038/nature14132

APA

Shungin, D., Winkler, T. W., Croteau-Chonka, D. C., Ferreira, T., Locke, A. E., Mägi, R., ... Mohlke, K. L. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518(7538), 187-U378. https://doi.org/10.1038/nature14132

CBE

Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, Workalemahu T, Wu JMW, Buchkovich ML, Heard-Costa NL, Roman TS, Drong AW, Song C, Gustafsson S, Day FR, Esko T, Fall T, Kutalik Z, Luan J, Randall JC, Scherag A, Vedantam S, Wood AR, Chen J, Fehrmann R, Karjalainen J, Kahali B, Liu C-T, Schmidt EM, Absher D, Amin N, Anderson D, Beekman M, Bragg-Gresham JL, Buyske S, Demirkan A, Ehret GB, Feitosa MF, Goel A, Jackson AU, Johnson T, Kleber ME, Kristiansson K, Mangino M, Mateo Leach I, Medina-Gomez C, Palmer CD, Pasko D, Pechlivanis S, Peters MJ, Prokopenko I, Stančáková A, Ju Sung Y, Tanaka T, Teumer A, Van Vliet-Ostaptchouk JV, Yengo L, Zhang W, Albrecht E, Ärnlöv J, Arscott GM, Bandinelli S, Barrett A, Bellis C, Bennett AJ, Berne C, Blüher M, Böhringer S, Bonnet F, Böttcher Y, Bruinenberg M, Carba DB, Caspersen IH, Clarke R, Daw EW, Deelen J, Deelman E, Delgado G, Doney ASF, Eklund N, Erdos MR, Estrada K, Eury E, Friedrich N, Garcia ME, Giedraitis V, Gigante B, Go AS, Golay A, Grallert H, Grammer TB, Gräßler J, Grewal J, Groves CJ, Haller T, Hallmans G, Hartman CA, Hassinen M, Hayward C, Heikkilä K, Herzig K-H, Helmer Q, Hillege HL, Holmen O, Hunt SC, Isaacs A, Ittermann T, James AL, Johansson I, Juliusdottir T, Kalafati I-P, Kinnunen L, Koenig W, Kooner IK, Kratzer W, Lamina C, Leander K, Lee NR, Lichtner P, Lind L, Lindström J, Lobbens S, Lorentzon M, Mach F, Magnusson PKE, Mahajan A, McArdle WL, Menni C, Merger S, Mihailov E, Milani L, Mills R, Moayyeri A, Monda KL, Mooijaart SP, Mühleisen TW, Mulas A, Müller G, Müller-Nurasyid M, Nagaraja R, Nalls MA, Narisu N, Glorioso N, Nolte IM, Olden M, Rayner NW, Renström F, Ried JS, Robertson NR, Rose LM, Sanna S, Scharnagl H, Scholtens S, Sennblad B, Seufferlein T, Sitlani CM, Vernon Smith A, Stirrups K, Stringham HM, Sundström J, Swertz MA, Swift AJ, Syvänen A-C, Tayo BO, Thorand B, Thorleifsson G, Tomaschitz A, Troffa C, van Oort FVA, Verweij N, Vonk JM, Waite LL, Wennauer R, Wilsgaard T, Wojczynski MK, Wong A, Zhang Q, Hua Zhao J, Brennan EP, Choi M, Eriksson P, Folkersen L, Franco-Cereceda A, Gharavi AG, Hedman ÅK, Hivert M-F, Huang J, Kanoni S, Karpe F, Keildson S, Kiryluk K, Liang L, Lifton RP, Ma B, McKnight AJ, McPherson R, Metspalu A, Min JL, Moffatt MF, Montgomery GW, Murabito JM, Nicholson G, Nyholt DR, Olsson C, Perry JRB, Reinmaa E, Salem RM, Sandholm N, Schadt EE, Scott RA, Stolk L, Vallejo EE, Westra H-J, Zondervan KT, Amouyel P, Arveiler D, Bakker SJL, Beilby J, Bergman RN, Blangero J, Brown MJ, Burnier M, Campbell H, Chakravarti A, Chines PS, Claudi-Boehm S, Collins FS, Crawford DC, Danesh J, de Faire U, de Geus EJC, Dörr M, Erbel R, Eriksson JG, Farrall M, Ferrannini E, Ferrières J, Forouhi NG, Forrester T, Franco OH, Gansevoort RT, Gieger C, Gudnason V, Haiman CA, Harris TB, Hattersley AT, Heliövaara M, Hicks AA, Hingorani AD, Hoffmann W, Hofman A, Homuth G, Humphries SE, Hyppönen E, Illig T, Jarvelin M-R, Johansen B, Jousilahti P, Jula AM, Kaprio J, Kee F, Keinanen-Kiukaanniemi SM, Kooner JS, Kooperberg C, Kovacs P, Kraja AT, Kumari M, Kuulasmaa K, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimäki T, Lyssenko V, Männistö S, Marette A, Matise TC, McKenzie CA, McKnight B, Musk AW, Möhlenkamp S, Morris AD, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Palmer LJ, Penninx BW, Peters A, Pramstaller PP, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ridker PM, Ritchie MD, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schwarz PEH, Shuldiner AR, Staessen JA, Steinthorsdottir V, Stolk RP, Strauch K, Tönjes A, Tremblay A, Tremoli E, Vohl M-C, Völker U, Vollenweider P, Wilson JF, Witteman JC, Adair LS, Bochud M, Boehm BO, Bornstein SR, Bouchard C, Cauchi S, Caulfield MJ, Chambers JC, Chasman DI, Cooper RS, Dedoussis G, Ferrucci L, Froguel P, Grabe H-J, Hamsten A, Hui J, Hveem K, Jöckel K-H, Kivimaki M, Kuh D, Laakso M, Liu Y, März W, Munroe PB, Njølstad I, Oostra BA, Palmer CNA, Pedersen NL, Perola M, Pérusse L, Peters U, Power C, Quertermous T, Rauramaa R, Rivadeneira F, Saaristo TE, Saleheen D, Sinisalo J, Slagboom PE, Snieder H, Spector TD, Thorsteinsdottir U, Stumvoll M, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Veronesi G, Walker M, Wareham NJ, Watkins H, Wichmann H-E, Abecasis GR, Assimes TL, Berndt SI, Boehnke M, Borecki IB, Deloukas P, Franke L, Frayling TM, Groop L, Hunter DJ, Kaplan RC, O'Connell JR, Qi L, Schlessinger D, Strachan DP, Stefansson K, van Duijn CM, Willer CJ, Visscher PM, Yang J, Hirschhorn JN, Zillikens MC, McCarthy MI, Speliotes EK, North KE, Fox CS, Barroso I, Franks PW, Ingelsson E, Heid IM, Loos RJF, Cupples LA, Morris AP, Lindgren CM, Mohlke KL. 2015. New genetic loci link adipose and insulin biology to body fat distribution. Nature. 518(7538):187-U378. https://doi.org/10.1038/nature14132

MLA

Vancouver

Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature. 2015;518(7538):187-U378. https://doi.org/10.1038/nature14132

Author

Shungin, Dmitry ; Winkler, Thomas W ; Croteau-Chonka, Damien C ; Ferreira, Teresa ; Locke, Adam E ; Mägi, Reedik ; Strawbridge, Rona J ; Pers, Tune H ; Fischer, Krista ; Justice, Anne E ; Workalemahu, Tsegaselassie ; Wu, Joseph M W ; Buchkovich, Martin L ; Heard-Costa, Nancy L ; Roman, Tamara S ; Drong, Alexander W ; Song, Ci ; Gustafsson, Stefan ; Day, Felix R ; Esko, Tonu ; Fall, Tove ; Kutalik, Zoltán ; Luan, Jian'an ; Randall, Joshua C ; Scherag, André ; Vedantam, Sailaja ; Wood, Andrew R ; Chen, Jin ; Fehrmann, Rudolf ; Karjalainen, Juha ; Kahali, Bratati ; Liu, Ching-Ti ; Schmidt, Ellen M ; Absher, Devin ; Amin, Najaf ; Anderson, Denise ; Beekman, Marian ; Bragg-Gresham, Jennifer L ; Buyske, Steven ; Demirkan, Ayse ; Ehret, Georg B ; Feitosa, Mary F ; Goel, Anuj ; Jackson, Anne U ; Johnson, Toby ; Kleber, Marcus E ; Kristiansson, Kati ; Mangino, Massimo ; Mateo Leach, Irene ; Medina-Gomez, Carolina ; Palmer, Cameron D ; Pasko, Dorota ; Pechlivanis, Sonali ; Peters, Marjolein J ; Prokopenko, Inga ; Stančáková, Alena ; Ju Sung, Yun ; Tanaka, Toshiko ; Teumer, Alexander ; Van Vliet-Ostaptchouk, Jana V ; Yengo, Loïc ; Zhang, Weihua ; Albrecht, Eva ; Ärnlöv, Johan ; Arscott, Gillian M ; Bandinelli, Stefania ; Barrett, Amy ; Bellis, Claire ; Bennett, Amanda J ; Berne, Christian ; Blüher, Matthias ; Böhringer, Stefan ; Bonnet, Fabrice ; Böttcher, Yvonne ; Bruinenberg, Marcel ; Carba, Delia B ; Caspersen, Ida H ; Clarke, Robert ; Daw, E Warwick ; Deelen, Joris ; Deelman, Ewa ; Delgado, Graciela ; Doney, Alex S F ; Eklund, Niina ; Erdos, Michael R ; Estrada, Karol ; Eury, Elodie ; Friedrich, Nele ; Garcia, Melissa E ; Giedraitis, Vilmantas ; Gigante, Bruna ; Go, Alan S ; Golay, Alain ; Grallert, Harald ; Grammer, Tanja B ; Gräßler, Jürgen ; Grewal, Jagvir ; Groves, Christopher J ; Haller, Toomas ; Hallmans, Goran ; Hartman, Catharina A ; Hassinen, Maija ; Hayward, Caroline ; Heikkilä, Kauko ; Herzig, Karl-Heinz ; Helmer, Quinta ; Hillege, Hans L ; Holmen, Oddgeir ; Hunt, Steven C ; Isaacs, Aaron ; Ittermann, Till ; James, Alan L ; Johansson, Ingegerd ; Juliusdottir, Thorhildur ; Kalafati, Ioanna-Panagiota ; Kinnunen, Leena ; Koenig, Wolfgang ; Kooner, Ishminder K ; Kratzer, Wolfgang ; Lamina, Claudia ; Leander, Karin ; Lee, Nanette R ; Lichtner, Peter ; Lind, Lars ; Lindström, Jaana ; Lobbens, Stéphane ; Lorentzon, Mattias ; Mach, François ; Magnusson, Patrik K E ; Mahajan, Anubha ; McArdle, Wendy L ; Menni, Cristina ; Merger, Sigrun ; Mihailov, Evelin ; Milani, Lili ; Mills, Rebecca ; Moayyeri, Alireza ; Monda, Keri L ; Mooijaart, Simon P ; Mühleisen, Thomas W ; Mulas, Antonella ; Müller, Gabriele ; Müller-Nurasyid, Martina ; Nagaraja, Ramaiah ; Nalls, Michael A ; Narisu, Narisu ; Glorioso, Nicola ; Nolte, Ilja M ; Olden, Matthias ; Rayner, Nigel W ; Renström, Frida ; Ried, Janina S ; Robertson, Neil R ; Rose, Lynda M ; Sanna, Serena ; Scharnagl, Hubert ; Scholtens, Salome ; Sennblad, Bengt ; Seufferlein, Thomas ; Sitlani, Colleen M ; Vernon Smith, Albert ; Stirrups, Kathleen ; Stringham, Heather M ; Sundström, Johan ; Swertz, Morris A ; Swift, Amy J ; Syvänen, Ann-Christine ; Tayo, Bamidele O ; Thorand, Barbara ; Thorleifsson, Gudmar ; Tomaschitz, Andreas ; Troffa, Chiara ; van Oort, Floor V A ; Verweij, Niek ; Vonk, Judith M ; Waite, Lindsay L ; Wennauer, Roman ; Wilsgaard, Tom ; Wojczynski, Mary K ; Wong, Andrew ; Zhang, Qunyuan ; Hua Zhao, Jing ; Brennan, Eoin P ; Choi, Murim ; Eriksson, Per ; Folkersen, Lasse ; Franco-Cereceda, Anders ; Gharavi, Ali G ; Hedman, Åsa K ; Hivert, Marie-France ; Huang, Jinyan ; Kanoni, Stavroula ; Karpe, Fredrik ; Keildson, Sarah ; Kiryluk, Krzysztof ; Liang, Liming ; Lifton, Richard P ; Ma, Baoshan ; McKnight, Amy J ; McPherson, Ruth ; Metspalu, Andres ; Min, Josine L ; Moffatt, Miriam F ; Montgomery, Grant W ; Murabito, Joanne M ; Nicholson, George ; Nyholt, Dale R ; Olsson, Christian ; Perry, John R B ; Reinmaa, Eva ; Salem, Rany M ; Sandholm, Niina ; Schadt, Eric E ; Scott, Robert A ; Stolk, Lisette ; Vallejo, Edgar E ; Westra, Harm-Jan ; Zondervan, Krina T ; Amouyel, Philippe ; Arveiler, Dominique ; Bakker, Stephan J L ; Beilby, John ; Bergman, Richard N ; Blangero, John ; Brown, Morris J ; Burnier, Michel ; Campbell, Harry ; Chakravarti, Aravinda ; Chines, Peter S ; Claudi-Boehm, Simone ; Collins, Francis S ; Crawford, Dana C ; Danesh, John ; de Faire, Ulf ; de Geus, Eco J C ; Dörr, Marcus ; Erbel, Raimund ; Eriksson, Johan G ; Farrall, Martin ; Ferrannini, Ele ; Ferrières, Jean ; Forouhi, Nita G ; Forrester, Terrence ; Franco, Oscar H ; Gansevoort, Ron T ; Gieger, Christian ; Gudnason, Vilmundur ; Haiman, Christopher A ; Harris, Tamara B ; Hattersley, Andrew T ; Heliövaara, Markku ; Hicks, Andrew A ; Hingorani, Aroon D ; Hoffmann, Wolfgang ; Hofman, Albert ; Homuth, Georg ; Humphries, Steve E ; Hyppönen, Elina ; Illig, Thomas ; Jarvelin, Marjo-Riitta ; Johansen, Berit ; Jousilahti, Pekka ; Jula, Antti M ; Kaprio, Jaakko ; Kee, Frank ; Keinanen-Kiukaanniemi, Sirkka M ; Kooner, Jaspal S ; Kooperberg, Charles ; Kovacs, Peter ; Kraja, Aldi T ; Kumari, Meena ; Kuulasmaa, Kari ; Kuusisto, Johanna ; Lakka, Timo A ; Langenberg, Claudia ; Le Marchand, Loic ; Lehtimäki, Terho ; Lyssenko, Valeriya ; Männistö, Satu ; Marette, André ; Matise, Tara C ; McKenzie, Colin A ; McKnight, Barbara ; Musk, Arthur W ; Möhlenkamp, Stefan ; Morris, Andrew D ; Nelis, Mari ; Ohlsson, Claes ; Oldehinkel, Albertine J ; Ong, Ken K ; Palmer, Lyle J ; Penninx, Brenda W ; Peters, Annette ; Pramstaller, Peter P ; Raitakari, Olli T ; Rankinen, Tuomo ; Rao, D C ; Rice, Treva K ; Ridker, Paul M ; Ritchie, Marylyn D ; Rudan, Igor ; Salomaa, Veikko ; Samani, Nilesh J ; Saramies, Jouko ; Sarzynski, Mark A ; Schwarz, Peter E H ; Shuldiner, Alan R ; Staessen, Jan A ; Steinthorsdottir, Valgerdur ; Stolk, Ronald P ; Strauch, Konstantin ; Tönjes, Anke ; Tremblay, Angelo ; Tremoli, Elena ; Vohl, Marie-Claude ; Völker, Uwe ; Vollenweider, Peter ; Wilson, James F ; Witteman, Jacqueline C ; Adair, Linda S ; Bochud, Murielle ; Boehm, Bernhard O ; Bornstein, Stefan R ; Bouchard, Claude ; Cauchi, Stéphane ; Caulfield, Mark J ; Chambers, John C ; Chasman, Daniel I ; Cooper, Richard S ; Dedoussis, George ; Ferrucci, Luigi ; Froguel, Philippe ; Grabe, Hans-Jörgen ; Hamsten, Anders ; Hui, Jennie ; Hveem, Kristian ; Jöckel, Karl-Heinz ; Kivimaki, Mika ; Kuh, Diana ; Laakso, Markku ; Liu, Yongmei ; März, Winfried ; Munroe, Patricia B ; Njølstad, Inger ; Oostra, Ben A ; Palmer, Colin N A ; Pedersen, Nancy L ; Perola, Markus ; Pérusse, Louis ; Peters, Ulrike ; Power, Chris ; Quertermous, Thomas ; Rauramaa, Rainer ; Rivadeneira, Fernando ; Saaristo, Timo E ; Saleheen, Danish ; Sinisalo, Juha ; Slagboom, P Eline ; Snieder, Harold ; Spector, Tim D ; Thorsteinsdottir, Unnur ; Stumvoll, Michael ; Tuomilehto, Jaakko ; Uitterlinden, André G ; Uusitupa, Matti ; van der Harst, Pim ; Veronesi, Giovanni ; Walker, Mark ; Wareham, Nicholas J ; Watkins, Hugh ; Wichmann, H-Erich ; Abecasis, Goncalo R ; Assimes, Themistocles L ; Berndt, Sonja I ; Boehnke, Michael ; Borecki, Ingrid B ; Deloukas, Panos ; Franke, Lude ; Frayling, Timothy M ; Groop, Leif ; Hunter, David J ; Kaplan, Robert C ; O'Connell, Jeffrey R ; Qi, Lu ; Schlessinger, David ; Strachan, David P ; Stefansson, Kari ; van Duijn, Cornelia M ; Willer, Cristen J ; Visscher, Peter M ; Yang, Jian ; Hirschhorn, Joel N ; Zillikens, M Carola ; McCarthy, Mark I ; Speliotes, Elizabeth K ; North, Kari E ; Fox, Caroline S ; Barroso, Inês ; Franks, Paul W ; Ingelsson, Erik ; Heid, Iris M ; Loos, Ruth J F ; Cupples, L Adrienne ; Morris, Andrew P ; Lindgren, Cecilia M ; Mohlke, Karen L. / New genetic loci link adipose and insulin biology to body fat distribution. I: Nature. 2015 ; Vol. 518, Nr. 7538. s. 187-U378.

RIS

TY - JOUR

T1 - New genetic loci link adipose and insulin biology to body fat distribution.

AU - Shungin, Dmitry

AU - Winkler, Thomas W

AU - Croteau-Chonka, Damien C

AU - Ferreira, Teresa

AU - Locke, Adam E

AU - Mägi, Reedik

AU - Strawbridge, Rona J

AU - Pers, Tune H

AU - Fischer, Krista

AU - Justice, Anne E

AU - Workalemahu, Tsegaselassie

AU - Wu, Joseph M W

AU - Buchkovich, Martin L

AU - Heard-Costa, Nancy L

AU - Roman, Tamara S

AU - Drong, Alexander W

AU - Song, Ci

AU - Gustafsson, Stefan

AU - Day, Felix R

AU - Esko, Tonu

AU - Fall, Tove

AU - Kutalik, Zoltán

AU - Luan, Jian'an

AU - Randall, Joshua C

AU - Scherag, André

AU - Vedantam, Sailaja

AU - Wood, Andrew R

AU - Chen, Jin

AU - Fehrmann, Rudolf

AU - Karjalainen, Juha

AU - Kahali, Bratati

AU - Liu, Ching-Ti

AU - Schmidt, Ellen M

AU - Absher, Devin

AU - Amin, Najaf

AU - Anderson, Denise

AU - Beekman, Marian

AU - Bragg-Gresham, Jennifer L

AU - Buyske, Steven

AU - Demirkan, Ayse

AU - Ehret, Georg B

AU - Feitosa, Mary F

AU - Goel, Anuj

AU - Jackson, Anne U

AU - Johnson, Toby

AU - Kleber, Marcus E

AU - Kristiansson, Kati

AU - Mangino, Massimo

AU - Mateo Leach, Irene

AU - Medina-Gomez, Carolina

AU - Palmer, Cameron D

AU - Pasko, Dorota

AU - Pechlivanis, Sonali

AU - Peters, Marjolein J

AU - Prokopenko, Inga

AU - Stančáková, Alena

AU - Ju Sung, Yun

AU - Tanaka, Toshiko

AU - Teumer, Alexander

AU - Van Vliet-Ostaptchouk, Jana V

AU - Yengo, Loïc

AU - Zhang, Weihua

AU - Albrecht, Eva

AU - Ärnlöv, Johan

AU - Arscott, Gillian M

AU - Bandinelli, Stefania

AU - Barrett, Amy

AU - Bellis, Claire

AU - Bennett, Amanda J

AU - Berne, Christian

AU - Blüher, Matthias

AU - Böhringer, Stefan

AU - Bonnet, Fabrice

AU - Böttcher, Yvonne

AU - Bruinenberg, Marcel

AU - Carba, Delia B

AU - Caspersen, Ida H

AU - Clarke, Robert

AU - Daw, E Warwick

AU - Deelen, Joris

AU - Deelman, Ewa

AU - Delgado, Graciela

AU - Doney, Alex S F

AU - Eklund, Niina

AU - Erdos, Michael R

AU - Estrada, Karol

AU - Eury, Elodie

AU - Friedrich, Nele

AU - Garcia, Melissa E

AU - Giedraitis, Vilmantas

AU - Gigante, Bruna

AU - Go, Alan S

AU - Golay, Alain

AU - Grallert, Harald

AU - Grammer, Tanja B

AU - Gräßler, Jürgen

AU - Grewal, Jagvir

AU - Groves, Christopher J

AU - Haller, Toomas

AU - Hallmans, Goran

AU - Hartman, Catharina A

AU - Hassinen, Maija

AU - Hayward, Caroline

AU - Heikkilä, Kauko

AU - Herzig, Karl-Heinz

AU - Helmer, Quinta

AU - Hillege, Hans L

AU - Holmen, Oddgeir

AU - Hunt, Steven C

AU - Isaacs, Aaron

AU - Ittermann, Till

AU - James, Alan L

AU - Johansson, Ingegerd

AU - Juliusdottir, Thorhildur

AU - Kalafati, Ioanna-Panagiota

AU - Kinnunen, Leena

AU - Koenig, Wolfgang

AU - Kooner, Ishminder K

AU - Kratzer, Wolfgang

AU - Lamina, Claudia

AU - Leander, Karin

AU - Lee, Nanette R

AU - Lichtner, Peter

AU - Lind, Lars

AU - Lindström, Jaana

AU - Lobbens, Stéphane

AU - Lorentzon, Mattias

AU - Mach, François

AU - Magnusson, Patrik K E

AU - Mahajan, Anubha

AU - McArdle, Wendy L

AU - Menni, Cristina

AU - Merger, Sigrun

AU - Mihailov, Evelin

AU - Milani, Lili

AU - Mills, Rebecca

AU - Moayyeri, Alireza

AU - Monda, Keri L

AU - Mooijaart, Simon P

AU - Mühleisen, Thomas W

AU - Mulas, Antonella

AU - Müller, Gabriele

AU - Müller-Nurasyid, Martina

AU - Nagaraja, Ramaiah

AU - Nalls, Michael A

AU - Narisu, Narisu

AU - Glorioso, Nicola

AU - Nolte, Ilja M

AU - Olden, Matthias

AU - Rayner, Nigel W

AU - Renström, Frida

AU - Ried, Janina S

AU - Robertson, Neil R

AU - Rose, Lynda M

AU - Sanna, Serena

AU - Scharnagl, Hubert

AU - Scholtens, Salome

AU - Sennblad, Bengt

AU - Seufferlein, Thomas

AU - Sitlani, Colleen M

AU - Vernon Smith, Albert

AU - Stirrups, Kathleen

AU - Stringham, Heather M

AU - Sundström, Johan

AU - Swertz, Morris A

AU - Swift, Amy J

AU - Syvänen, Ann-Christine

AU - Tayo, Bamidele O

AU - Thorand, Barbara

AU - Thorleifsson, Gudmar

AU - Tomaschitz, Andreas

AU - Troffa, Chiara

AU - van Oort, Floor V A

AU - Verweij, Niek

AU - Vonk, Judith M

AU - Waite, Lindsay L

AU - Wennauer, Roman

AU - Wilsgaard, Tom

AU - Wojczynski, Mary K

AU - Wong, Andrew

AU - Zhang, Qunyuan

AU - Hua Zhao, Jing

AU - Brennan, Eoin P

AU - Choi, Murim

AU - Eriksson, Per

AU - Folkersen, Lasse

AU - Franco-Cereceda, Anders

AU - Gharavi, Ali G

AU - Hedman, Åsa K

AU - Hivert, Marie-France

AU - Huang, Jinyan

AU - Kanoni, Stavroula

AU - Karpe, Fredrik

AU - Keildson, Sarah

AU - Kiryluk, Krzysztof

AU - Liang, Liming

AU - Lifton, Richard P

AU - Ma, Baoshan

AU - McKnight, Amy J

AU - McPherson, Ruth

AU - Metspalu, Andres

AU - Min, Josine L

AU - Moffatt, Miriam F

AU - Montgomery, Grant W

AU - Murabito, Joanne M

AU - Nicholson, George

AU - Nyholt, Dale R

AU - Olsson, Christian

AU - Perry, John R B

AU - Reinmaa, Eva

AU - Salem, Rany M

AU - Sandholm, Niina

AU - Schadt, Eric E

AU - Scott, Robert A

AU - Stolk, Lisette

AU - Vallejo, Edgar E

AU - Westra, Harm-Jan

AU - Zondervan, Krina T

AU - Amouyel, Philippe

AU - Arveiler, Dominique

AU - Bakker, Stephan J L

AU - Beilby, John

AU - Bergman, Richard N

AU - Blangero, John

AU - Brown, Morris J

AU - Burnier, Michel

AU - Campbell, Harry

AU - Chakravarti, Aravinda

AU - Chines, Peter S

AU - Claudi-Boehm, Simone

AU - Collins, Francis S

AU - Crawford, Dana C

AU - Danesh, John

AU - de Faire, Ulf

AU - de Geus, Eco J C

AU - Dörr, Marcus

AU - Erbel, Raimund

AU - Eriksson, Johan G

AU - Farrall, Martin

AU - Ferrannini, Ele

AU - Ferrières, Jean

AU - Forouhi, Nita G

AU - Forrester, Terrence

AU - Franco, Oscar H

AU - Gansevoort, Ron T

AU - Gieger, Christian

AU - Gudnason, Vilmundur

AU - Haiman, Christopher A

AU - Harris, Tamara B

AU - Hattersley, Andrew T

AU - Heliövaara, Markku

AU - Hicks, Andrew A

AU - Hingorani, Aroon D

AU - Hoffmann, Wolfgang

AU - Hofman, Albert

AU - Homuth, Georg

AU - Humphries, Steve E

AU - Hyppönen, Elina

AU - Illig, Thomas

AU - Jarvelin, Marjo-Riitta

AU - Johansen, Berit

AU - Jousilahti, Pekka

AU - Jula, Antti M

AU - Kaprio, Jaakko

AU - Kee, Frank

AU - Keinanen-Kiukaanniemi, Sirkka M

AU - Kooner, Jaspal S

AU - Kooperberg, Charles

AU - Kovacs, Peter

AU - Kraja, Aldi T

AU - Kumari, Meena

AU - Kuulasmaa, Kari

AU - Kuusisto, Johanna

AU - Lakka, Timo A

AU - Langenberg, Claudia

AU - Le Marchand, Loic

AU - Lehtimäki, Terho

AU - Lyssenko, Valeriya

AU - Männistö, Satu

AU - Marette, André

AU - Matise, Tara C

AU - McKenzie, Colin A

AU - McKnight, Barbara

AU - Musk, Arthur W

AU - Möhlenkamp, Stefan

AU - Morris, Andrew D

AU - Nelis, Mari

AU - Ohlsson, Claes

AU - Oldehinkel, Albertine J

AU - Ong, Ken K

AU - Palmer, Lyle J

AU - Penninx, Brenda W

AU - Peters, Annette

AU - Pramstaller, Peter P

AU - Raitakari, Olli T

AU - Rankinen, Tuomo

AU - Rao, D C

AU - Rice, Treva K

AU - Ridker, Paul M

AU - Ritchie, Marylyn D

AU - Rudan, Igor

AU - Salomaa, Veikko

AU - Samani, Nilesh J

AU - Saramies, Jouko

AU - Sarzynski, Mark A

AU - Schwarz, Peter E H

AU - Shuldiner, Alan R

AU - Staessen, Jan A

AU - Steinthorsdottir, Valgerdur

AU - Stolk, Ronald P

AU - Strauch, Konstantin

AU - Tönjes, Anke

AU - Tremblay, Angelo

AU - Tremoli, Elena

AU - Vohl, Marie-Claude

AU - Völker, Uwe

AU - Vollenweider, Peter

AU - Wilson, James F

AU - Witteman, Jacqueline C

AU - Adair, Linda S

AU - Bochud, Murielle

AU - Boehm, Bernhard O

AU - Bornstein, Stefan R

AU - Bouchard, Claude

AU - Cauchi, Stéphane

AU - Caulfield, Mark J

AU - Chambers, John C

AU - Chasman, Daniel I

AU - Cooper, Richard S

AU - Dedoussis, George

AU - Ferrucci, Luigi

AU - Froguel, Philippe

AU - Grabe, Hans-Jörgen

AU - Hamsten, Anders

AU - Hui, Jennie

AU - Hveem, Kristian

AU - Jöckel, Karl-Heinz

AU - Kivimaki, Mika

AU - Kuh, Diana

AU - Laakso, Markku

AU - Liu, Yongmei

AU - März, Winfried

AU - Munroe, Patricia B

AU - Njølstad, Inger

AU - Oostra, Ben A

AU - Palmer, Colin N A

AU - Pedersen, Nancy L

AU - Perola, Markus

AU - Pérusse, Louis

AU - Peters, Ulrike

AU - Power, Chris

AU - Quertermous, Thomas

AU - Rauramaa, Rainer

AU - Rivadeneira, Fernando

AU - Saaristo, Timo E

AU - Saleheen, Danish

AU - Sinisalo, Juha

AU - Slagboom, P Eline

AU - Snieder, Harold

AU - Spector, Tim D

AU - Thorsteinsdottir, Unnur

AU - Stumvoll, Michael

AU - Tuomilehto, Jaakko

AU - Uitterlinden, André G

AU - Uusitupa, Matti

AU - van der Harst, Pim

AU - Veronesi, Giovanni

AU - Walker, Mark

AU - Wareham, Nicholas J

AU - Watkins, Hugh

AU - Wichmann, H-Erich

AU - Abecasis, Goncalo R

AU - Assimes, Themistocles L

AU - Berndt, Sonja I

AU - Boehnke, Michael

AU - Borecki, Ingrid B

AU - Deloukas, Panos

AU - Franke, Lude

AU - Frayling, Timothy M

AU - Groop, Leif

AU - Hunter, David J

AU - Kaplan, Robert C

AU - O'Connell, Jeffrey R

AU - Qi, Lu

AU - Schlessinger, David

AU - Strachan, David P

AU - Stefansson, Kari

AU - van Duijn, Cornelia M

AU - Willer, Cristen J

AU - Visscher, Peter M

AU - Yang, Jian

AU - Hirschhorn, Joel N

AU - Zillikens, M Carola

AU - McCarthy, Mark I

AU - Speliotes, Elizabeth K

AU - North, Kari E

AU - Fox, Caroline S

AU - Barroso, Inês

AU - Franks, Paul W

AU - Ingelsson, Erik

AU - Heid, Iris M

AU - Loos, Ruth J F

AU - Cupples, L Adrienne

AU - Morris, Andrew P

AU - Lindgren, Cecilia M

AU - Mohlke, Karen L

PY - 2015

Y1 - 2015

N2 - Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

AB - Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

KW - Obesity: genetics

KW - Physiologic: genetics

KW - Neovascularization

KW - Insulin Resistance: genetics

KW - Insulin: metabolism

KW - Human: genetics

KW - Genome

KW - Europe: ethnology

KW - Continental Population Groups: genetics

KW - Adipose Tissue: metabolism

KW - Adipocytes: metabolism

KW - Adipogenesis: genetics

KW - Polymorphism

KW - Single Nucleotide: genetics

KW - Quantitative Trait Loci: genetics

KW - Transcription

KW - Genetic: genetics

U2 - 10.1038/nature14132

DO - 10.1038/nature14132

M3 - Article

VL - 518

SP - 187-U378

JO - Nature

T2 - Nature

JF - Nature

SN - 0028-0836

IS - 7538

ER -