New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1–like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for up to 50% of previously unclassified pediatric BCP-ALL cases.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Regional Laboratories Region Skåne
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Hematologi
  • Cancer och onkologi
Originalspråkengelska
Sidor (från-till)1395-1401
TidskriftBlood
Volym130
Utgivningsnummer12
StatusPublished - 2017 sep 21
PublikationskategoriForskning
Peer review utfördJa