NMR spectroscopy in inhomogeneous B-0 and B-1 fields with non-linear correlation

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Abstract

Resolved NMR spectra from samples in inhomogeneous B-0 and B-1 fields can be obtained with the so-called "ex situ" methodology, employing a train of composite or adiabatic z-rotation RF pulses to periodically refocus the inhomogeneous broadening during the detection of the time-domain signal. Earlier schemes relied on a linear correlation between the inhomogeneous B0 and B, fields. Here the pulse length, bandwidth, and amplitude of the adiabatic pulses of the hyperbolic secant type are adjusted to improve the refocusing for a setup with non-linear correlation. The field correlation is measured using a two-dimensional nutation experiment augmented with a third dimension with varying RF carrier frequency accounting for off-resonance effects. The pulse optimization is performed with a computer algorithm using the experimentally determined field correlation and a standard adiabatic z-rotation pulse as a starting point for the iterative optimization procedure. The shape of the z-rotation RF pulse is manipulated to provide refocusing for the conditions given by the sample-, magnet-, and RF-coil geometry. (c) 2005 Elsevier Inc. All rights reserved.

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  • Fysikalisk kemi
Originalspråkengelska
Sidor (från-till)1-10
TidskriftJournal of Magnetic Resonance
Volym175
Utgåva nummer1
StatusPublished - 2005
PublikationskategoriForskning
Peer review utfördJa