NMR Study of the Sorption Behavior of Benzyl Alcohol Derivatives into Sonicated and Extruded Dioctadecyldimethylammonium Chloride (DODAC) Dispersions: The Relevance of Membrane Fluidity.

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The sorption behavior of three benzyl alcohol derivatives with different hydrophobicities into sonicated and extruded DODAC dispersions has been studied using NMR spectroscopy and NMR diffusometry. We show that there is an increased sorption into a sonicated dispersion below the phase-transition temperature (Tm) as compared to an extruded dispersion. This may be explained by the incomplete lipid chain freezing of charged lipids as a result of the sonication process. Around Tm, a sorption maximum is found that is attributed to the high bilayer disorder under this condition. In addition, a sorption increase and a fluidizing effect at increasing benzyl alcohol derivative concentrations are observed that provide additional evidence for the relevance of the bilayer fluidity on the sorption of hydrophobic components.


  • Pieter Saveyn
  • Ellen Cocquyt
  • Davy Sinnaeve
  • José Martins
  • Daniel Topgaard
  • Paul Meeren
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Fysikalisk kemi
Sidor (från-till)3082-3089
Utgåva nummer7
StatusPublished - 2008
Peer review utfördJa