No association between moist oral snuff (snus) use and oral cancer: pooled analysis of nine prospective observational studies

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Aims: Worldwide, smokeless-tobacco use is a major risk factor for oral cancer. Evidence regarding the particular association between Swedish snus use and oral cancer is, however, less clear. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between snus use and oral cancer. Methods: A total of 418,369 male participants from nine cohort studies were followed up for oral cancer incidence through linkage to health registers. We used shared frailty models with random effects at the study level, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for confounding factors. Results: During 9,201,647 person-years of observation, 628 men developed oral cancer. Compared to never-snus use, ever-snus use was not associated with oral cancer (adjusted HR 0.90, 95% CI: 0.74, 1.09). There were no clear trends in risk with duration or intensity of snus use, although lower intensity use (⩽ 4 cans/week) was associated with a reduced risk (HR 0.65, 95% CI: 0.45, 0.94). Snus use was not associated with oral cancer among never smokers (HR 0.87, 95% CI: 0.57, 1.32). Conclusions: Swedish snus use does not appear to be implicated in the development of oral cancer in men.

Detaljer

Författare
  • Marzieh Araghi
  • Maria Rosaria Galanti
  • Michael Lundberg
  • Zhiwei Liu
  • Weimin Ye
  • Anton Lager
  • Gunnar Engström
  • Lars Alfredsson
  • Anders Knutsson
  • Margareta Norberg
  • Patrik Wennberg
  • Ylva Trolle Lagerros
  • Rino Bellocco
  • Nancy L. Pedersen
  • Per Olof Östergren
  • Cecilia Magnusson
Enheter & grupper
Externa organisationer
  • Karolinska Institute
  • Umeå University
  • Karolinska University Hospital
  • University of Milano-Bicocca
  • Stockholms läns sjukvårdsområde
  • Mittuniversitetet
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

Nyckelord

Originalspråkengelska
TidskriftScandinavian Journal of Public Health
StatusE-pub ahead of print - 2020 maj 28
PublikationskategoriForskning
Peer review utfördJa