No evidence for new dopaminergic neurons in the adult mammalian substantia nigra.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

A recent report by Zhao et al. [Zhao, M., Momma, S., Delfani, K., Carlen, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisen, J. & Janson, A. M. (2003) Proc. Natl. Acad. Sci. USA 100, 7925–7930] suggests that dopaminergic neurons, the cell type lost in Parkinson's disease, are continuously generated in the adult substantia nigra pars compacta. Using similar methodological procedures to label dividing cells, we found no evidence of new dopaminergic neurons in the substantia nigra, either in normal or 6-hydroxydopamine-lesioned hemi-Parkinsonian rodents, or even after growth factor treatment. Furthermore, we found no evidence of neural stem cells emanating from the cerebroventricular system and migrating to the substantia nigra. We conclude that it is unlikely that dopaminergic neurons are generated in the adult mammalian substantia nigra.

Detaljer

Författare
  • Helena Frielingsdorf
  • Katherine Schwarz
  • Patrik Brundin
  • Paul Mohapel
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper
Originalspråkengelska
Sidor (från-till)10177-10182
TidskriftProceedings of the National Academy of Sciences
Volym101
Utgivningsnummer27
StatusPublished - 2004
PublikationskategoriForskning
Peer review utfördJa