Non-invasive imaging methodologies for assessment of radiation damage to bone marrow and kidneys from peptide receptor radionuclide therapy. -

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Background/Aims: Peptide receptor radionuclide therapy (PRRT) is becoming clinical routine for management of Neuroendocrine Tumours. The number of PRRT cycles are correlated with treatment effect but theoretically limited by off-target radiation damage to kidneys and bone marrow. New imaging biomarkers for assessment of PRRT tissue damage would enable evaluation of novel renal and bone marrow protective agents, as well as personalized PRRT treatment regiments. METHODS: Mice treated with [177Lu]Lu-DOTA-TATE PRRT or vehicle were examined at baseline and following treatment with [18F]FLT PET and [99mTc]Tc-Mag3 SPECT to assess dynamic changes in bone marrow proliferation and renal function, respectively. RESULTS: Bone marrow proliferation as assessed by [18F]FLT was decreased two days after PRRT treatment, but not vehicle, compared to baseline (Target-to-Background ratio (TBRmax) baseline:1.69±0.29 vs TBRmax PRRT: 0.91±0.02, p<0.01). Renal function as assessed by [99mTc]Tc-Mag3 SPECT was similarly decreased two days following PRRT compared to vehicle (Fractional Uptake Rate (FUR) vehicle: 0.030±0.014 s-1 vs FUR PRRT: 0.0051±0.0028 s-1, p<0.01). CONCLUSION: [18F]FLT PET and [99mTc]Tc-Mag3 SPECT are promising techniques for assessing bone marrow and renal injury from [177Lu]Lu-DOTA-TATE PRRT, and may potentially improve patient management by allowing evaluation of protective interventions as well as enabling personalized PRRT treatments.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Antaros Medical AB
  • A1M Pharma AB
  • Science for Life Laboratory
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Radiologi och bildbehandling

Nyckelord

  • Peptide receptor radionuclide therapy · Radiation damage · Positron emission tomography · Single-photon emission tomography · Renal protection
Originalspråkengelska
Sidor (från-till)1-9
TidskriftNeuroendocrinology
StatusPublished - 2019 apr 19
PublikationskategoriForskning
Peer review utfördJa