Non-Lamellar lipid assembly at interfaces: Controlling layer structure by responsive nanogel particles

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Biological membranes do not only occur as planar bilayer structures, but depending on the lipid composition, can also curve into intriguing threedimensional structures. In order to fully understand the biological implications as well as to reveal the full potential for applications, e.g. for drug delivery and other biomedical devices, of such structures, well-defined model systems are required. Here, we discuss the formation of lipid nonlamellar liquid crystalline (LC) surface layers spin-coated from the constituting lipids followed by hydration of the lipid layer. We demonstrate that hybrid lipid polymer films can be formed with different properties compared with the neat lipid LC layers. The nanostructure and morphologies of the lipid films formed reflect those in the bulk. Most notably, mixed lipid layers, which are composed of glycerol monooleate and diglycerol monooleate with poly(N-isopropylacrylamide) nanogels, can form films of reverse cubic phases that are capable of responding to temperature stimulus. Owing to the presence of the nanogel particles, changing the temperature not only regulates the hydration of the cubic phase lipid films, but also the lateral organization of the lipid domains within the lipid self-assembled film. This opens up the possibility for new nanostructured materials based on lipid-polymer responsive layers.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Institut Laue Langevin
  • Uppsala universitet, Historiska institutionen
  • Malmö University
  • Camurus AB
  • Rutherford Appleton Laboratory
  • Murdoch University
  • University of Florence
  • Research Center for Colloids and Nanoscience
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Polymerkemi
  • Fysikalisk kemi

Nyckelord

Originalspråkengelska
TidskriftInterface Focus
Volym7
Utgåva nummer4
StatusPublished - 2017
PublikationskategoriForskning
Peer review utfördJa